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  • About
    • Mission & Goals
    • Associate Laboratory
    • Governance
    • Infrastructure
    • Contact us
  • People
    • Faculty
    • Researchers
    • PhD Students
    • Alumni
    • Support Team
  • Research
    • Research Groups
      • Bioprocess Engineering
      • Biological Sciences
      • Biocatalysis and Biotransformation
      • Biospectroscopy and Interfaces
      • Stem Cell Engineering
    • Publications
      • Peer-reviewed publications
      • Books & Book Chapters
      • PhD Theses
      • Oral communications
    • Funded Projects
      • National Projects
      • International Projects
  • Innovation
    • Bridging Innovation and Industry
    • Collaborative Laboratories
    • Research Infrastructures
  • Education
    • PhD Programmes
    • MSc Degrees
    • Advanced Training
  • News & Events
    • News
    • Events
    • Media
iBB

Biospectroscopy and Interfaces Research Group

(BSIRG)

Electronic and vibrational spectroscopies, including fluorescence spectroscopy and microscopy (i), Molecular and Cellular Biophysics (ii), Biomaterials and Nanomedicine (iii).

Keywords

Fluorescence

Cellular and Molecular Biophysics

Biomembranes and Interfaces

Biomaterials

Coordinator

Mário Nuno Berberan  |  berberan@tecnico.ulisboa.pt

Goals

The Biospectroscopy and Interfaces Research Group (BSIRG)

BSIRG’s research focuses both on fundamental science (spectroscopy, biomolecules, structure and dynamics of nanosystems and biomaterials) and on Human Health (new drugs and nanotherapeutics). Some of the research lines are:

(i) Development of new scintillator materials, and their application in detectors including medical devices (e.g. X-ray and gamma detectors);

(ii) Engineering of extracellular vesicle (EV)-mimic nanoparticles obtained from plasma membrane ectosomes with the goal of accelerating the translation of EV-inspired nanoparticle technologies;

(iii) Development of innovative single-molecule approaches for describing Intrinsically Disordered Proteins involved in neurodegeneration;

(iv) Study of novel anticancer nanoformulations targeting colorectal cancer and glioblastoma;

(v) Development of anti-biofilm drugs such as antimicrobial dendrimers, quorum-sensing inhibitors (QSI) and efflux pump inhibitors.

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Outreach

Major Contributions

Structural  characterization of amyloid and amyloid-like protein fibers

Sensors and OLEDs based on fluorescence

Nanoscale organization of biological and biomimetic membranes

Focus Areas

Characterization of lipid-protein and protein-protein interactions

Study and development of novel cationic antimicrobial peptides

Development of new bio and nanostructured materials, fluorescent probes and OLEDs

Synthesis/characterization of photosensitizers

Publications

Selected Publications

Marcos, P. M., & Berberan-Santos, M. N. (2023). Fluorescent homooxacalixarenes: Recent applications in supramolecular systems. Frontiers in Chemistry, 11, 1258026. https://doi.org/10.3389/fchem.2023.1258026

Pinto, S. N., Mil-Homens, D., Pires, R. F., Alves, M. M., Serafim, G., Martinho, N., Melo, M., Fialho, A. M., & Bonifácio, V. D. B. (2022). Core–shell polycationic polyurea pharmadendrimers: New-generation of sustainable broad-spectrum antibiotics and antifungals. Biomaterials Science, 10(18), 5197–5207. https://doi.org/10.1039/D2BM00679K

Lima, M., Avó, J., Berberan-Santos, M. N. M. S., & Crucho, C. I. C. (2022). pH-Responsive Silica Coatings: A Generic Approach for Smart Protection of Colloidal Nanoparticles. ACS Applied Nano Materials, 5(7), 9460–9468. https://doi.org/10.1021/acsanm.2c01723

Borges-Araújo, L., Domingues, M. M., Fedorov, A., Santos, N. C., Melo, M. N., & Fernandes, F. (2021). Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains. Communications Chemistry, 4(1), 164. https://doi.org/10.1038/s42004-021-00603-1

Scanavachi, G., Coutinho, A., Fedorov, A. A., Prieto, M., Melo, A. M., & Itri, R. (2021). Lipid Hydroperoxide Compromises the Membrane Structure Organization and Softens Bending Rigidity. Langmuir, 37(33), 9952–9963. https://doi.org/10.1021/acs.langmuir.1c00830

Projects

  • Ongoing Projects
  • Completed Projects
Ongoing Projects

AntiMatter-Otech

Novel High-Luminosity Photonics for AntiMatter-OTech Opaque Neutrino Detection
BSIRG
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Ml4NGP

Non-globular proteins in the era of Machine Learning
BSIRG
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NanoSPace

Carbon molecular nanostructures in space
BSIRG
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Completed Projects

BioNanoLip

Bioactive lipids at the ocular surface: from Langmuir surface balance to ophthalmic nanoemulsions
BSIRG
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DEFENSE

Nanomateriais com Fluorescencia Atrasada para Sistemas de Imagiologia e Detecção
BSIRG
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DendriCare

Next generation of antibiofilm agents: Multivalent dendrimers with antimicrobial and biofilm disruption activity
BSIRG
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DREAM

Dendrímeros Inteligentes para Nanoteranóstica do Cancro
BSIRG
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LIPOX

Lipid Oxidation in membrane and cell Biophysics: From Functional nanosensors to the impact on amyloid formation. Application of advanced fluorescence, X-Ray scattering and microscopy Techniques
BSIRG
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LipReleaseTau

The role of the plasma membrane in the unconventional secretion of tau: insights into the progression of tauopathies
BSIRG
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People

The BSIRG Team

Coordinator

Mário Nuno Berberan  |  berberan@tecnico.ulisboa.pt

Research Group Website
Biospectroscopy and Interfaces (BSIRG)
Adriana Cruz

Adriana Cruz

PhD Student
iBB Group: bsirg
Profile
Ana Coutinho

Ana Coutinho

Collaborating researcher, assistant professor
iBB Group: bsirg
Profile
L-3755-2014
Ana Melo

Ana Melo

assistant researcher
iBB Group: bsirg
Profile
Q-6580-2017
Diogo Filipe

Diogo Filipe

PhD Student
iBB Group: bsirg
Profile
Diogo Gonçalves

Diogo Gonçalves

PhD Student
iBB Group: bsirg
Profile
GQI-2487-2022
Fábio Fernandes

Fábio Fernandes

assistant professor
iBB Group: bsirg
Profile
J-6358-2012
Hélio Barros

Hélio Barros

assistant researcher
iBB Group: bsirg
Profile
AAO-7163-2201
Isabel Luísa Machado

Isabel Luísa Machado

collaborating researcher
iBB Group: bsirg
Profile
0000-0001-7527-9489
Luís Filipe Ferreira

Luís Filipe Ferreira

associate professor, retired professor
iBB Group: bsirg
Profile
A-8788-2014
Manuel Prieto

Manuel Prieto

Full professor, retired professor
iBB Group: bsirg
Profile
N-4448-2013

Margarida Marques

PhD Student
iBB Group: bsirg
Profile

Maria Carvalho

PhD Student
iBB Group: bsirg
Profile
Mário Santos

Mário Berberan Santos

full professor
iBB Group: bsirg
Profile
B-3810-2008
Natércia Lopes

Natércia Lopes

assistant researcher
iBB Group: bsirg
Profile
AAG-1464-2021

Pedro Rosa

PhD Student
iBB Group: bsirg
Profile
Ricardo Silva

Ricardo Silva

PhD Student
iBB Group: bsirg
Profile
Sandra Pinto

Sandra Pinto

assistant researcher
iBB Group: bsirg
Profile
H-8446-2016
Vasco Bonifácio

Vasco Bonifácio

assistant professor
iBB Group: bsirg
Profile
AE14-EB30-86A6

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iBB aims to excel in research and advanced education in biotechnology, by responding to the challenge of exploring innovative approaches to key scientific and technological questions in Biosciences and Bioengineering and of transforming scientific knowledge into tangible innovation.

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