Tooth and periodontal diseases, such as caries, defects, and periodontitis, affect billions of people worldwide and remain major clinical and socio-economic burdens. When poorly treated, they frequently lead to tooth loss.
Regenerative dentistry is emerging as a promising alternative, combining tissue engineering, stem cell biology, and biophysical stimulation to restore oral health.
In a recent review published in Cells, iBB researchers Rúben Pires, Mafalda Santos, Filipe Miguel, Cláudia Lobato da Silva, and João Carlos Silva examined how oral tissue-derived mesenchymal stem/stromal cells (OMSCs) respond to electrical stimulation (ES), a biophysical cue known to influence cell migration, proliferation, and differentiation.
Link to paper: https://www.mdpi.com/2073-4409/14/11/840
The paper discusses:
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Biological responses of OMSCs under ES
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Breakthroughs in ES-based dental and periodontal regeneration
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Key challenges and future directions for clinical translation
This work was supported by Fundação para a Ciência e a Tecnologia (FCT) through the projects InSilico4OCReg (PTDC/EME-SIS/0838/2021) and DentalBioMatrix (PTDC/BTM-MAT/3538/2020).