Theranostics is an emerging medical concept, combining imaging and therapy for personalized medicine. Considering the need for highly targeted therapy in cancer, the main objective of the project is the development new tools for one step imaging and therapy directed towards tumors (theranostic approach).

Taking advantage of the huge biomedical potential and versatility of nanoparticles (NPs) and of fluorescent porphyrins as photosensitizers (PSs), we will bring improved joint power by designing, producing and characterizing porphyrin/biopolymer-coated iron oxide NPs, exhibiting superior imaging and photodynamic properties in solid tumors.

As secondary objectives, 1) we will build a multidisciplinary network in the field of nanotheranostics; 2) to train and to sustain career development for young researchers; 3) to obtain scientific and economic advantages for partner institutions, both academia and SMEs.

The project is in line with the M-era.Net topic “Tailoring of bioactive material surfaces for health applications” by developing a new/improved (nano)solution with multifunctional properties for theranostics in cancer. It will be demonstrated at preclinical level (in vitro and in animal models), addressing both therapeutic efficacy and toxicological issues.