Acronym AMELIE Title A targeted regenerative approach for treating incontinence Summary

Faecal incontinence (FI) is the inability to control bowel movement, causing leakage of faeces. The EU-funded AMELIE project comprises a highly interdisciplinary consortium of experts who are proposing a novel regenerative intervention using autologous skeletal muscle derived cells (ASMDC) to restore the function of the sphincter muscle. Scientists will attach ASMDC to implantable microcarriers to improve cell delivery and engraftment in patients with FI. This will be tested in a randomised clinical trial. The strategy is expected to improve cell viability and increase the likelihood of muscle regeneration, contributing to improved continence.

Project webpage Open project webpage Start year 01/09/2020 End year 31/08/2025 ID ID: 874807 iBB Role Partner iBB Budget 452 360,00 € Research Group SCERG PI Joaquim Cabral Project Partners UCL- University College London, Aarhus Universitet, Ttopstart bv, Centre Hospitalier Universitaire de Rouen, IISFJD- Instituto Investigacion Sanitaria Fundacion Jimenez Diaz, Medizinische Universitat Graz, Bowel Research UK, CBVF- Consorzio per Valutazioni Biologiche e Farmacologiche, Aarhus Universitets Hospital, NHS blood and transplant, Queen Mary University of London, Universitatsklinikum Erlangen Status Ongoing Funding European Commission