Evguenia Bekman

Collaborating Researcher, Assistant professor

O-9840-2017

Web of Science profile

iBB Group: scerg

evguenia.bekman@tecnico.ulisboa.pt

Expertise: Pluripotent stem cells, neuronal differentiation, gene editing, brain organoids, CRISPR/Cas9

Short Bio:

Evguenia Bekman has PhD in Biomedical Sciences from Oporto University and Master in Biology/ Embryology from Moscow University MM Lomonosov. She is a senior researcher at the IBB, Lisbon University, and assistant professor at Egas Moniz School of Health and Science, Monte de Caparica. She has a long-standing record in neuronal differentiation, using both embryonic stem cells (ES) and induced pluripotent stem cells (iPSCs). She also has an expertise in BAC recombineering and CRISPR/Cas9 gene engineering. Her research is focused on establishing brain organoid models from patient iPS cells for unravelling disease mechanisms and new therapeutics for neurodevelopmental disorders.

ORCID

SCOPUS

CIÊNCIA VITAE

Research Focus:

My main focus is to develop brain organoid models derived from patient iPSCs for unravelling of disease mechanisms and new therapeutic approaches for neurodevelopmental disorders.

“Stem cell toolkit for modelling cerebellar dysfunction in Angelman Syndrome” , Angelman syndrome Grant 2022 awarded by Angelman Syndrome Alliance (ASA)
PMJMCD Fellowship 2019 awarded by Fundação Amélia de Mello for the project: “Exploring new therapeutic strategies for Angelman syndrome: A disease modelling approach based on 3D cerebellar organoids derived from patient iPSCs”

Maranga, C., et al. (2022). Generation and characterization of induced pluripotent stem cell line (IBBISTi004-A) from an Angelman syndrome patient carrying a class II deletion of the maternal chromosome 15q11.2-q13. Stem Cell Research 61:102757. http://dx.doi.org/10.1016/j.scr.2022.102757

Silva, T.P., et al. (2021).Transcriptome profiling of human pluripotent stem cell-derived cerebellar organoids reveals faster commitment under dynamic conditions. Biotechnology and Bioengineering. http://dx.doi.org/10.1002/bit.27797

Miranda, C.C., et al. (2020). hiPSC-Based Model of Prenatal Exposure to Cannabinoids: Effect on Neuronal Differentiation Frontiers in Molecular Neuroscience. http://dx.doi.org/10.3389/fnmol.2020.00119

Silva, T. P., et al. (2020). Maturation of Human Pluripotent Stem Cell-Derived Cerebellar Neurons in the Absence of Co-culture. Frontiers in Bioengineering and Biotechnology 8. https://dx.doi.org/10.3389/fbioe.2020.00070

Abranches, E., et al. (2009). Neural Differentiation of Embryonic Stem Cells In Vitro: A Road Map to Neurogenesis in the Embryo. PLoS ONE 4(7): e6286. https://dx.doi.org/10.1371/journal.pone.0006286

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Evguenia Bekman