M. Ângela Taipa

assistant professor

L-5574-2013

iBB Group: berg

angela.taipa@tecnico.ulisboa.pt

Expertise: Biomolecular Engineering, Molecular recognition, Biomimetic affinity ligands, Purification/stabilization of proteins, Immunoprocesses

Short Bio:

M. Ângela Taipa earned a B.Sc. degree in Chemical Engineering (1989), a Ph.D. in Biotechnology (1997) and a Tenure as Assistant Professor in 2002, by Instituto Superior Técnico. She joined the new Department of Bioengineering in 2011 and became a member of the Institute for Bioengineering and Biosciences in 2013. Her scientific expertise covers areas such as animal cell culture/hybridoma production, ligand-protein affinity interactions, and purification/characterization (biochemical, kinetic, spectroscopic) of enzymes and immunoglobulins. Over the years, Ângela Taipa has conducted scientific research in these fields, participating in or leading different funded projects and supervising several bachelor's, master's and doctoral theses.

Research Focus:

Production, purification and characterization of biomolecules with potential application in the health/blue economy sectors. Combinatorial synthesis/ screening of biomimetic affinity ligands for identification/stabilization of proteins.

ChiCoBionts – Harnessing the catalyst power of host-microbe interactions: a quest for novel chitinases from octocoral symbionts (Co-PI) 2022-2023. Contract EXPL/BIA-MIC/0286/2021Url: http://doi.org/10.54499/EXPL/BIA-MIC/0286/2021

Biomimetic Affinity Polymer Systems for Molecular Recognition of Antibodies (PI) 2007-2011. Contract 3599-PPCDT/64822/PT
Url: https://app.dimensions.ai/details/grant/grant.3532794

Design of Stabilizing Affinity Molecular Probes : A Rational Approach to Assess and Enhance Protein Stability (PI) 2004-2008. Contract POCI/45296/PT

Purification of immunologlobulin subclasses by innovative affinity methodologies based on biomimetic ligands (PI) 2001-2004. Contract POCI/36199/PT

Bioartificial pancreas: Preliminary studies of hemocompatibility, diffusion and immunoisolation (Researcher – Team Member) 2000-2002. Contract PRAXIS/P/BIO/12007/1998

Fonseca, L.P., Taipa, M.Â. (2024). One-Step Purification of Recombinant Cutinase from an E. coli Extract Using a Stabilizing Triazine-Scaffolded Synthetic Affinity Ligand. Biomimetics, 9 (1), 57. https://doi.org/10.3390/biomimetics9010057

da Silva, D.M.G., Pedrosa, F.R., Taipa, M.Â., Costa R., Keller-Costa, T. (2023). Widespread occurrence of chitinase-encoding genes suggests the Endozoicomonadaceae family as a key player in chitin processing in the marine benthos. ISME Communications 3 (1), 109.
https://doi.org/10.1038/s43705-023-00316-7

Taipa, M. Â., Azevedo, A.M., Grilo, A.L., Couto, P.T.; Ferreira, F.A.G.; Fortuna, A. R.M., Pinto, I.F.; Santos, R.M.; Santos, S.B. (2015). Student Collaboration in a Series of Integrated Experiments To Study Enzyme Reactor Modeling with Immobilized Cell-Based Invertase. J Chem Education, 92, (7), 1238-1243.
http://dx.doi.org/10.1021/ed500842p

Silva, C.S.O., Lansalot, M., Garcia, J.Q., Taipa, M.Â*., Martinho, J.M.G.* (2013). Synthesis and characterization of biomimetic nanogels for immunorecognition. Colloids and Surfaces B: Biointerfaces, 112, 264-271.
http://dx.doi.org/10.1016/j.colsurfb.2013.08.003

Roque, A.C.A., Silva, C.S.O., Taipa, M.Â. (2007). Affinity-based methodologies and ligands for antibody purification: Advances and perspectives. J Chromat A, 1160 (1-2), 44-55. http://dx.doi.org/10.1016/j.chroma.2007.05.109

iBB People

M. Ângela Taipa