During marine bioprocess development, pH control is of paramount importance. However, the use of traditional buffers, such as phosphate buffer, can lead to the precipitation of medium components.
In a recently published paper, Ricardo Pereira and Carla C.C.R. de Carvalho from iBB-Institute for Bioengineering and Biosciences, used lipidomics analysis in conjugation with statistical multivariate analysis to determine the cellular response to pH variations and buffer composition.
Good’s buffers were found to be a sound alternative to phosphate buffer, allowing higher productivities in the model system tested.
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