A recent article published in Pharmaceutical Research by Pedro Fonte’s team presents a novel strategy to treat pulmonary tuberculosis through inhalable polymer nanoparticles.
The study reports the development of a dry powder formulation designed for deep lung delivery, enabling controlled and sustained release of N-acetylcysteine (NAC). The formulation demonstrated improved lung deposition, enhanced particle flowability, and superior antibacterial activity against Mycobacterium tuberculosis.
This work, conducted within the framework of an international collaboration, highlights the potential of nanoparticle-based delivery systems to advance tuberculosis therapy and provide more effective, patient-friendly treatment solutions.
Read the full paper at: https://link.springer.com/article/10.1007/s11095-025-03889-1