Expertise: Molecular Biology, DNA nanostructures, Plasmonic Nanoparticles
Thesis: TropoCount - An Optofluidic Assay for Miocardial Infarction Diagnosis based on Aptamer Actuated DNA Origami Plasmonic Nanosensors
Thesis Advisor: Pedro Paulo (CQE), Miguel Prazeres, João Fonseca (Biosurfit)
Company: Biosurfit
Short Bio:
Having completed a Masters Degree in Microbiology at the Instituto Superior Técnico of the University of Lisbon, José Santos began his research career as an assistant working under the Lactosynt project at iBB, working on the development of a genome editing system for use in lactic acid bacteria. More recently, he has leveraged his experience in molecular biology into the design and construction of DNA origami nanostructures. He intends to combine these with plasmonic gold nanoparticles to construct novel biosensors for detection of disease biomarkers.
Research Focus:
Research on nanobiotechnology, focusing on DNA origami and their applications. Currently helping develop novel biosensors using plasmonic nanoparticles arranged on a DNA origami scaffold.
Lactosynt (PTDC/BTMSAL/ 28624/2017): Lactic acid bacteria as cell factories: a Synthetic Biology Approach for Plasmid DNA and Recombinant Protein Production
NanoSensRNA (2022.04076.PTDC): A Gold Nanosensor for Single-Molecule Detection of RNA Biomarkers in a Miniaturized Microscope
Santos, José (2019) CRISPR/Cas9-based genome editing of lactic acid bacteria for the improvement of biopharmaceutical-grade plasmid and recombinant protein production. [Master's Thesis, Instituto Superior Técnico da Universidade de Lisboa]. https://fenix.tecnico.ulisboa.pt/cursos/microbio/dissertacao/283828618790285