Tiago Matos

Assistant Professor

iBB Group: berg

tiagobmatos@tecnico.ulisboa.pt

Expertise: Process development, digital transformation, biochemistry, modeling, continuous manufacturing

Short Bio:

Tiago Matos has over 10 years of experience in the pharmaceutical industry, and an outstanding record of published manuscripts, patents, and international awards. Tiago Matos has focused on various areas, including nucleic acids, enzymes, antibodies, and vaccines, with a strong emphasis on process development and smart processing. With a strong background in biochemistry, i leverage a deep molecular understanding to enhance process design and develop control strategies in the digital era. Currently focuses in driving the implementation of next-generation technologies. Our primary objective is to facilitate necessary transformations during the process development, aiming to establish more robust, efficient, faster, and advanced process development and characterization through new methods and technologies, such digital twins. This approach takes control strategies to the next level in the realm of digitalization. This new digital transformation aims to expedite drug deployment, minimize errors and costs, and promote accessibility to advancements in the pharmaceutical industry. These efforts will significantly contribute to shaping the future of drug development and manufacturing processes through digital innovation. Awards: Gold Award at SBCN conference 2013 and Best industry Poster Award at PREP 2019.

ORCID

CIÊNCIA VITAE

GOOGLE SCHOLAR

Research Focus:

Smart Manufacturing, Process development, Digital processing, Industry 4.0, Biopharma.

Athalye, S. M., Maruthamuthu, M. K., Esmaili, E., Boodaghidizaji, M., Sarathy, N., Mayorga, C., Raffaele, J., Selvamani, V., Smith, J. P., Matos, T., Rustandi, R. R., Ardekani, A. M., & Verma, M. S. (2026). Real-time monitoring of attenuated cytomegalovirus using Raman spectroscopy allows non-destructive characterization during flow. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 345, 126761. https://doi.org/10.1016/j.saa.2025.126761

Taylor, R., Mandur, J., Amira, U., Al‐Inati, N., Marin‐Celis, J., Hatch, S., Cerezo, L. F., Pinto, N., Metsi‐Guckel, E., Matos, T., Brower, M., Mehta, K., & Sarkar, A. (2025). Use of live digital twin (shadow) soft sensor to monitor membrane degradation in continuous manufacturing single pass tangential flow filtration. Biotechnology Progress, e70058. https://doi.org/10.1002/btpr.70058

Kim, T., Esmaili, E., Athalye, S. M., Matos, T., Hosseini, M., Verma, M. S., & Ardekani, A. M. (2024). Acoustofluidic device focusing viral nanoparticles for Raman microscopy. Sensors and Actuators B: Chemical, 420, 136438. https://doi.org/10.1016/j.snb.2024.136438

Matos, T., Hoying, D., Kristopeit, A., Wenger, M., & Joyce, J. (2023). Continuous multi-membrane chromatography of large viral particles. Journal of Chromatography A, 1705, 464194. https://doi.org/10.1016/j.chroma.2023.464194

iBB People

Tiago Matos