Teresa Pinheiro

assistant researcher

O-8984-2019

Web of Science profile

iBB Group: bsrg

teresa.pinheiro@tecnico.ulisboa.pt

Expertise: - Multimodal imaging- Three-Dimensional Nuclear Microscopy - Cell irradiation - Biomarkers - Radiosensitizers for target proton therapy

Short Bio:

Teresa Pinheiro's research activities are focused on three main areas: Biomedicine, Biophysics, and Bioimaging. She searches for innovative technology with the potential to revolutionise medical imaging and ionising radiation treatments. Imaging probes, including fluorescent, X-ray, mass spectrometry and nuclear microscopy modalities are being used to explore the potential of metal complexes/nanoplatforms as radiosensitizers by assessing their uptake and spatial distribution in 2D and 3D cell models. In addition, the irradiating of cells with different types of radiation can aid in the identification of a set of biomarkers relevant to radiosensitization. This offers new possibilities for assessing personalised diagnostic and therapeutic protocols for cancer treatment.

Research Focus:

Metal complexes/nanoplatforms as radiosensitizers; 2D and 3D cell models; multimodal microscopy; cellular response to radiation; Machine learning to classify heart disease.

BORN: B/Fe/Au Multifunctional Nanoplatforms for Proton/Photon Therapy: Imaging and Irradiation Using Cancer Cell Models (IAEA consortium F11024, contract 26800)
https://www.iaea.org/projects/crp/f11024

Pinheiro, T., Alves, L.C., Corregidor, V., Teixidor, F., Viñas, C., Marques, F. (2023, March 9) Metallacarboranes for proton therapy using research accelerators: a pilot study. EPJ Techn Instrum., 10, 5. https://doi.org/10.1140/epjti/s40485-023-00093-6

Sousa, A., Santos, J.F., Silva, F., Sousa, S.A., Leitão, J.H., Matos, A.P., Pinheiro, T., Silva, R.A.L., Belo, D., Almeida, M., Marques, F., Fernandes, C. (2023, February 8) Antitumoral and Antimicrobial Activities of Block Copolymer Micelles Containing Gold Bisdithiolate Complexes. Pharmaceutics, 15(2),564, https://doi.org/10.3390/pharmaceutics15020564

Machado, J.F., Marques, F., Pinheiro, T., Villa de Brito, M.J., Scalese, G., Pérez-Díaz, L., Otero, L., António, J.P.M., Gambino, D., Morais, T.S. (2023, July 17) Copper(I)-Thiosemicarbazone Complexes with Dual Anticancer and Antiparasitic Activity. Chem. Med. Chem., 18(14) e202300074. https://doi.org/10.1002/cmdc.202300074

Nuez-Martínez, M., Queralt-Martín, M., Muñoz-Juan, A., Aguilella, V.M., Laromaine, A., Teixidor, F., Viñas, C., Pinto, C.G., Pinheiro, T., Guerreiro, J.F., Mendes, F., Roma-Rodrigues, C., Baptista, P.V., Fernandes, A.R., Valic, S., Marques, F. (2022, December 21 ) Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma. J. Mater. Chem. B, 10(47), 9794-9815, https://doi.org/10.1039/D2TB01818G (Article included in Journal of Materials Chemistry B 2022 Most Popular Articles collection and ‘Most popular’ anniversary collection; Frontal cover of the issue Journal of Materials Chemistry B Volume 10 Number 47, 21 December 2022).

Buades, A., Pereira, L.C.J., Vieira, B.J. C., Cerdeira, A.C., Waerenborgh, J.C., Pinheiro, T., Matos, A.P.A., Pinto, C.G., Guerreiro, J.F., Mendes, F., Valic, S., Teixidor, F., Viñas, C., Marques, F. (2022, February 4) The Mössbauer effect using 57Fe-ferrabisdicarbollide ([o-57FESAN]−): a glance into the potential of a low-dose approach for glioblastoma radiotherapy. Inorg. Chem. Front., 9(7), 1490-1503. DOI:10.1039/D1QI01513C.

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Teresa Pinheiro