Sofia Duarte

Sofia Oliveira Dias Duarte

assistant researcher

ITU-8370-2023

Web of Science profile

iBB Group: berg

sofia.duarte@tecnico.ulisboa.pt

Expertise: NanotechnologyDrug delivery systemsSynthetic BiologyGenome editingLactic Acid Bacteria

Short Bio:

Sofia Duarte earned her PhD from Instituto Superior Técnico (IST), with her thesis on using synthetic biology in Lactic Acid Bacteria. She also holds a Master's in Applied Microbiology and a degree in Biology (Molecular Biology and Genetics), both from Faculdade de Ciências da Universidade de Lisboa.Currently, as a Post-Doctoral Researcher at IST, Sofia focuses on nanotechnology in biomedical and bioengineering applications. She's leading innovative projects in nanoparticle-based drug delivery systems for diseases like diabetes and type-2 inflammation. Previously, she contributed significantly to bacteriophage production for pre-clinical trials, specializing in purification techniques and endotoxin removal.

Research Focus:

Develop and apply nanotechnology-based approaches for biomedical and bioengineering applications.

LactoSynt: Lactic Acid Bacteria as Cell Factories: a Synthetic Biology Approach for Plasmid DNA and Recombinant Protein Production (PTDC/BTM-SAL/28624/2017)

A Synthetic Biology based approach to construct a Lactic Acid Bacteria/artificial plasmid platform for the production of plasmid DNA and recombinant proteins (UID/BIO/04565/2013)

SYNBIOBACTHER: Synthetic biology approaches to engineer “therapeutic” bacteria (PTDC/EBB-BIO/102863/2008)

Kumar, M., Virmani, T., Kumar, G., Deshmukh, R., Sharma, A., Duarte, S., Brandão, P. & Fonte, P. (2023). Nanocarriers in Tuberculosis Treatment: Challenges and Delivery Strategies. Pharmaceuticals, 16(10), 1360.

Viegas, C., Patrício, A. B., Prata, J., Fonseca, L., Macedo, A. S., Duarte, S. O., & Fonte, P. (2023). Advances in Pancreatic Cancer Treatment by Nano-Based Drug Delivery Systems. Pharmaceutics, 15(9), 2363.

Monteiro, G. A., & Duarte, S. O. (2022). The Effect of Recombinant Protein Production in Lactococcus lactis Transcriptome and Proteome. Microorganisms, 10(2), 267.

Duarte, S. O., & Monteiro, G. A. (2021). Plasmid replicons for the production of pharmaceutical-grade pDNA, proteins and antigens by Lactococcus lactis cell factories. International Journal of Molecular Sciences, 22(3), 1379.

Duarte, S. O., Martins, M. C., Andrade, S. M., Prazeres, D. M., & Monteiro, G. A. (2019). Plasmid Copy Number of pTRKH3 in Lactococcus lactis is Increased by Modification of the repDE Ribosome‐Binding Site. Biotechnology Journal, 14(8), 1800587.

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Sofia Oliveira Dias Duarte