Simão T. Rocha
Ongoing PI Grants:
X-HUMAN – Dissecting the molecular mechanisms of X-chromosome inactivation using human embryonic stem cells (2022.01532.PTDC)
STEM_CELL_ANGEL – Stem cell toolkit for modelling cerebellar dysfunction in Angelman Syndrome (Angelman syndrome Grant 2022)
Ongoing co-PI Grants:
PWS_Metabolite – Role of microbial metabolites in regulating hypothalamic pathways involved in feeding behavior (1029673)
https://www.fpwr.org/fpwr-funded-projects/role-of-microbial-metabolites-in-regulating-hypothalamic-pathways-involved-in-feeding-behavior
Ongoing Grants as Senior Researcher:
EURAS – EUropean network for neurodevelopmental RASopathies (101080580)
https://www.euras-project.eu/
Rocha, S. T. (2022). Imprinting fidelity in mouse iPSCs depends on sex of donor cell and medium formulation. Nat Commun, 13(1), 5432. doi:10.1038/s41467-022-33013-5
Bousard, A., Raposo, A. C., Zylicz, J. J., Picard, C., Pires, V. B., Qi, Y., . . . da Rocha, S. T. (2019). The role of Xist-mediated Polycomb recruitment in the initiation of X-chromosome inactivation. EMBO Rep, 20(10), e48019. doi:10.15252/embr.201948019
Klobucar, T., Kreibich, E., Krueger, F., Arez, M., Polvora-Brandao, D., von Meyenn, F., . . . Eckersley-Maslin, M. (2020). IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions. Nucleic Acids Res, 48(16), e92. doi:10.1093/nar/gkaa567
Maranga, C., Pereira, C., Raposo, A. C., Vieira, A., Duarte, S., Bekman, E. P., . . . da Rocha, S. T. (2022). Generation and characterization of induced pluripotent stem cell line (IBBISTi004-A) from an Angelman syndrome patient carrying a class II deletion of the maternal chromosome 15q11.2-q13. Stem Cell Res, 61, 102757. doi:10.1016/j.scr.2022.102757
Polvora-Brandao, D., Joaquim, M., Godinho, I., Aprile, D., Alvaro, A. R., Onofre, I., . . . da Rocha, S. T. (2018). Loss of hierarchical imprinting regulation at the Prader-Willi/Angelman syndrome locus in human iPSCs. Hum Mol Genet, 27(23), 3999-4011. doi:10.1093/hmg/ddy274