Samantha Mancino

assistant researcher

iBB Group: scerg

samantha.mancino@tecnico.ulisboa.pt

Expertise: Molecular Neuroscience, Genomic imprinting, Brain organoids, Prader-Willi Syndrome, Compulsive Eating behavior

Short Bio:

Samantha Mancino, a dedicated neuroscientist specializing in addiction, compulsive eating, and epigenetics holds a PhD from Pompeu Fabra University. As a postdoctoral researcher at Boston University School of Medicine and the University of Milan, she delved into binge eating and neurotoxicology. Awarded the Fondazione Veronesi postdoctoral fellowship in 2017, she investigated cognition deficits and inflammation. Joining the MC Fonseca – da Rocha group, Samantha secured an FCT junior research contract focusing on Prader Willi Syndrome and eating disorders, blending neuroscience and epigenetics. Her work aims to unveil insights into these conditions, paving the way for innovative tools and understanding.

Research Focus:

Understanding the neuropathological impact of epi/genetic alterations in cellular models of imprinting diseases such as Prader-Willi syndrome

2021.02356.CEECIND individual project awarded by Portuguese Foundation for Science and Technology (FCT): “The role of SNORD115 in processing the serotonin 2C receptor: insights for eating disorders and Prader-Willi Syndrome pathogenesis”.
Individual Postdoctoral Fellowship 2018 awarded by Fondazione Umberto Veronesi for the project: “Modulation of the interaction of the IL1RI – GluN2B / NMDAR complex: role in neuroinflammation”

Mancino S et al. 2024,Stability of Genomic Imprinting and X-Chromosome Inactivation in the Aging Brain (under publication). Aging Cell.

Mancino S et al. 2024, Dualistic SAHA dose-dependent effects on glial-inflammatory response: a microarray comparative study (under publication). Journal of Inflammation Research.

Arez M et al. 2022, Imprinting fidelity in mouse iPSCs depends on sex of donor cell and medium formulation.
Nature Communications.

Mancino S et al. 2019, Neuron-Glia Interactions Studied with In Vitro Co-Cultures. Book Chapter in
Neuromethods – Springer New York.

Mancino S et al. 2017, A behavioral and pharmacological characterization of palatable diet alternation in
mice. Pharmachology Biochemistry and Behavior.
– Mancino S et al. 2016, Role of DOR in neuronal plasticity changes promoted by food-seeking behaviour.
Addiction Biology.

Mancino S et al. 2015, Epigenetic and proteomic expression changes promoted by eating addictive-like
behavior. Neuropsychopharmacology.

Gutiérrez-Cuesta et al. 2014, Effects of genetic deletion of endogenous opioid system components on the reinstatement of cocaine-seeking behavior in mice. Neuropsychopharmacology.

Mancino S et al. 2012, Modelling food addiction in mice. Conference Paper in Behavioural Pharmacology.

iBB People

Samantha Mancino