Nuno Mira

Nuno Pereira Mira

associate professor

E-2965-2012

Web of Science profile

iBB Group: bsrg

nuno.mira@tecnico.ulisboa.pt

Expertise: Yeast biology and Physiology; Genomics; Pathway prospection; anti-Candida therapies

Short Bio:

Nuno Mira obtained his PhD in Biotechnology and Biosciences in 2008. In 2011 he was appointed Assistant Professor and in 2022 Associate Professor, both positions at the Dept. of Bioengineering at IST. Mira’s team uses genomics-oriented approaches to develop new biotechnological applications centred in Yeasts including: i) engineering of robust industrial Yeast strains to produce high economic value bulk chemicals of interest (e.g. bio-flavourants or carboxylic acids) including “new-to-nature” molecules for which computation-assisted synthetic pathways had to be designed; ii) development of new anti-Candida treatments using knowledge-based approaches, with emphasis on those based on lactobacilii species indigenous to the human microbiome

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CIÊNCIA VITAE

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Research Focus:

Yeast-centered biotechnology

SMARTWINE 2.0 – Tailoring 2-in-1 new Yeast starter cultures for production of distinct “greenly-preserved” wines, funded by FCT in the 2022 competitive call (2022.06777.PTDC)
TRAMONTE – Valorização dos recursos biológicos do interior Norte: a Tramazeira como case-study; PD21-000013, funded by Fundação LaCaixa together with BPI and FCT, within the scope of the program PROMOVE o interior

PHARMAPITOX – Desenvolvimento de um coletor inovador e protocolo para purificação da apitoxina para uso nas indústrias farmacêutica e cosmética, LISBOA-01-0247-FEDER-113540,

LactoCan – Exploring the interference between Candida spp. and lactobacilii to foster the development of non-conventional antifungal therapies, PTDC/BIA-MIC/31515/2017

TTRAFFIC – Toxicity and Transport for Fungal Production of Industrial Compounds (EraNet in Industrial Biotechnology; ERA-IB-2-6/0003/2014)(PI of the Portuguese team)

Pedro N, Fontebasso G, Pinto SN, Alves MM, Mira NP, (2023), Acetate modulates the inhibitory effect of Lactobacillus gasseri against the pathogenic yeasts Candida albicans and Candida glabrata, Microbial Cell, 10(4):88-102;

Vila-Santa A., Islam MA, Ferreira FC, Prather KJ and Mira NP, (2021), Prospecting biochemical pathways to implement microbe-based production of the new-to-nature platform chemical levulinic acid, ACS Synthetic Biology, 10, 4, 724–736,

Tavares MJ, Guldener U, Mendes-Ferreira A and Mira NP, (2021), Genome sequencing, annotation and exploration of the SO2-tolerant non-conventional yeast Saccharomycodes ludwigii, BMC Genomics, 22: 131

Salazar SB, Pinheiro MJF, Novais D, Soares AR, Lopes MM, Ferreira T, Rodrigues V, Fernandes F and Mira NP, 2022, Disclosing azole resistance mechanisms in resistant C. glabrata strains encoding wild-type or gain-of-function CgPDR1 alleles through comparative genomics and transcriptomics, G3: Genes, Genomes and Genetics, 12:7

Sun W, Vila-Santa A, Liu N, Prozorov T, Xie D, Faria NT, Ferreira FC, Mira NP and Shao Z, (2020), Metabolic engineering of an acid-tolerant yeast strain Pichia kudriavzevii for itaconic acid production, Metabolic Engineering Communications, 10:e00124

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Nuno Pereira Mira