Miguel Teixeira

Miguel Cacho Teixeira

full professor

A-3870-2008

Web of Science profile

iBB Group: bsrg

mnpct@tecnico.ulisboa.pt

Expertise: Yeast physiology and Molecular Biology, Clinical Microbiology, Genetics and Genomics, Transcriptomics and Proteomics, Systems Biology

Short Bio:

Miguel Cacho Teixeira received BSc and PhD degrees in Chemical Engineering and Biotechnology from the Technical University of Lisbon, Lisbon, Portugal, in 2000 and 2004, respectively. He is currently full professor at the Bioengineering Department of Instituto Superior Técnico (IST), University of Lisbon. He is also senior researcher at iBB - Institute for Bioengineering and Biosciences, Biological Sciences Research Group, IST. His research interests focus the molecular basis of drug resistance and stress tolerance in the model yeast S. cerevisiae, and of virulence and biofilm formation in pathogenic yeasts of the Candida genus. Miguel's research makes ample use of genome-wide analysis and systems biology tools, aiming the design of optimized cell factories and the improvement of diagnosis and therapy for the treatment of fungal infections.

Research Focus:

Research onto the cellular and molecular basis of yeast phenotypes, relevant in clinical or biotechnological contexts, in a systems biology perspective

PTDC/BII-BIO/28216/2017: “MIXED-UP – Targeting pathogenesis and engineering cell factories: by developing mixed regulatory-metabolic genomic models in yeasts” (PI).

PTDC/BBB-BIO/4004/2014: “CANTROL – Deciphering the mechanisms of transcriptional regulation that control antifungal drug resistance in the pathogenic yeast Candida glabrata: aiming the development of improved diagnosis and therapeutic approaches” (PI).

PTDC/EBB-BIO/119356/2010: “FUNDRING – Identification of new biomarkers of antiFUNgal Drug Resistance diagnosis IN Candida Glabrata: the particular role of multidrug resistance transporters” (PI).

Teixeira, M.C.**, Viana, R., Palma, M., Oliveira, J., Galocha, M., Mota, M.N., Couceiro, D., Pereira, M.G., Antunes, M., Costa, I.V., Pais, P., Parada, C., Chaouiya, C., Sá-Correia, I.**, Monteiro, P.T.**, “YEASTRACT+: a portal for the exploitation of global transcription regulation and metabolic model data in yeast biotechnology and pathogenesis”, Nucleic Acids Research, gkac1041, 2023.

Galocha, M., Viana, R., Pais, P., Silva-Dias, A., Cavalheiro, M., Miranda, I.M., Van Ende, M., Souza, C.S., Costa, C., Branco, J., Soares, C.M., Van Dijck, P., Rodrigues, A.G.**, Teixeira, M.C.**, “Genomic evolution towards azole resistance in Candida glabrata clinical isolates unveils the importance of CgHxt4/6/7 in azole accumulation”, Communications Biology, 5: 1118, 2022.

Cavalheiro, M., Pereira, D., Formosa-Dague, C., Leitão, C., Pais, P., Ndlovu, E., Viana, R., Pimenta, A.I., Santos, R., Takahashi-Nakaguchi, A., Michiyo Okamoto , Mihaela Ola , Chibana, H., Fialho, A.M., Butler, G., Dague, E.**, Teixeira, M.C.**, “From the first touch to biofilm establishment by the human pathogen Candida glabrata: a genome-wide to nanoscale view”, Communications Biology, 4: 886, 2021.

Pais, P., Vagueiro, S., Mil-Homens, D., Pimenta, A.I., Viana, R., Okamoto, M., Chibana, H., Fialho, A.M., Teixeira, M.C., “A new regulator in the crossroads of oxidative stress resistance and virulence in Candida glabrata: the transcription factor CgTog1”, Virulence, 11(1):1522-1538, 2020.

Viana, R., Dias, O., Lagoa, D., Galocha, M., Rocha, I., Teixeira, M.C., “Genome-scale metabolic model of the human pathogen Candida albicans: a platform for drug target prediction”, Journal of Fungi, 6: 171, 2020.

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Miguel Cacho Teixeira