Duarte Miguel Prazeres

Duarte Miguel F. Prazeres

full professor

E-2526-2011

Web of Science profile

iBB Group: berg

miguelprazeres@tecnico.ulisboa.pt

Expertise: Biosensing, Biorecognition, Biomanufacturing, Bioprocess Engineering, Downstream Processing

Short Bio:

Miguel Prazeres is a principal investigator in the Biomolecular Engineering, Bioprocess Engineering and Nanobiotechnology fields. With a Ph.D. in Chemical Engineering (1993) and the Habilitation in Chemical Engineering (2003) from Instituto Superior Técnico (IST), Miguel’s work revolves around the Biomanufacturing of Nucleic Acid, and Biosensing and diagnostics. In the first topic, the focus is on the engineering of bioprocesses and bacterial strains for the manufacturing of plasmid DNA, minicircles, mRNA and dsRNA. In the second topic the focus is on the development of biologically based diagnostic systems (e.g. lateral flow assays, paper-based devices).

Research Focus:

Biomanufacturing of nucleic acids for gene and cell therapy applications & development of biologically based diagnostic systems.

CBM-X: Biorecognition as a Tool for the Functionalization of Cellulose-based Materials with Biomolecules and Nanostructures (PTDC/CTM-CTM/30790/2017), https://www.scoop.it/topic/ibb/?&tag=CBM-X000
LFA4Covid: Development of a Lateral Flow Assay working prototype for detection of antibodies to SARS-CoV-2 (Research 4 Covid-19, N. 576)

On2Off: Nanomagnets: Development and application of nanomagnets and ferrofluids with an “on-to-off” variation of magnetization around room-temperature (project 02/SAICT/2017/029460)

CBM Sensor Paper: Desenvolvimento de nova plataforma para imobilização de biomoléculas sobre celulose” (Agência de Inovação, project 30270)

Silva-Santos, A. R., Oliveira-Silva, P., Paulo, P. M. R., Prazeres, D. M. F. (2021). Affinity-based magnetic particles for the purification of single stranded DNA scaffolds for biomanufacturing DNA-origami nanostructures. ACS Applied Nanomaterials, 4, 14169–14177. https://doi.org/10.1021/acsanm.1c03623

Natarajan, S., Jayaraj, J., Prazeres, D. M. F. (2022). Exploring carbohydrate-binding module fusions and Fab fragments in cellulose-based lateral flow immunoassay for detection of cystatin C, Scientific Reports, 12, 5478. https://doi.org/10.1038/s41598-022-09454-9

Silva-Santos, A.R., Paulo, P. M. R., Prazeres, D. M. F. (2022). Scalable purification of single stranded DNA scaffolds for biomanufacturing DNA-origami nanostructures: Exploring anion-exchange and multimodal chromatography. Sep. Pur. Technol., 298, 121623. https://doi.org/10.1016/j.seppur.2022.121623

Rosa, S. S., Nunes, D., Antunes, L., Prazeres, D. M. F., Marques, M. P. C., Azevedo, A. M. (2022). Maximising mRNA vaccine production with Bayesian optimization. Biotechnol. Bioeng., 119, 3127-3139. https://doi.org/10.1002/bit.28216

Oliveira-Silva, R., Wang, Y., Nooteboom, S.W., Prazeres, D.M.F., Paulo, P.M.R., Zijlstra, P. (2023). Single-particle plasmon sensor to monitor proteolytic activity in real-time. ACS App. Opt. Mat., 1, 1661-1669. https://doi.org/10.1021/acsaom.3c00226

iBB People

Duarte Miguel F. Prazeres