Marília Mateus

assistant professor

K-8463-2012

iBB Group: 2brg

marilia.mateus@tecnico.ulisboa.pt

Expertise: Microbial bioreactors, Ultrafiltration/Nanofiltration, Membrane chromatography, Biopharmaceuticals, Algae-derived functional ingredients

Short Bio:

Marília Mateus is Assistant Professor at the Department of Bioengineering of Instituto Superior Técnico, ULisboa, and researcher at the Institute for Bioengineering and Biosciences. She graduated in Chemical Engineering (1984), further obtaining a Biotechnology–Biochemical Engineering masters’ degree (1988) and a PhD in Chemical Engineering (1994). During her career, she pursued advances in bioprocessing focusing on microbial culturing/immobilization, bioreactor operation, downstream strategies (membrane filtration, chromatography) targeting bioproduct purification, and process integration. Following her strong food technology knowledge and industrial technology transfer experience, she develops biorefinery approaches towards food/feed ingredients and investigates molecular/process design for safe and effective fish-farming vaccines.

ORCID

SCOPUS

CIÊNCIA VITAE

Research Focus:

Design/production/encapsulation of r-proteins and of p-DNA for effective and sustainable aquaculture vaccines; Separation and recovery of functional-components from fermented biomass (partition strategies using green-solvents).

PROMISEANG: Alternative PROteins from MIcrobial fermentation of non-conventional SEA sources for Next-Generation food, feed and non-food bio-based applications (HORIZON-JU-CBE-2022; ID 101112378), https://cordis.europa.eu/project/id/101112378

SMART SEAWEED: Smart valorisation of macroalgae (FA_05_2017:033), https://www.smartseaweed.net/

PureMab: Multimodal chromatography as an alternative to pure chromatographic modes for the capture and polishing of antibody streams (PTDC/QEQ-PRS/0286/2014), https://app.dimensions.ai/details/grant/grant.4682369

Improvement of the immunogenicity of DNA vaccines (PTDC/EBB-EBI/113650/2009), https://app.dimensions.ai/details/grant/grant.3528280

Membrane chromatographic matrices for plasmid-DNA purification: rational design based on biochemical and biophysical interactions (PTDC/EBB-EBI/100925/2008), https://app.dimensions.ai/details/grant/grant.3530803

Santo, G. E., Barros, A., Costa, M., Pereira, H., Trovão, M., Cardoso, H., Carvalho, B., Soares, M., Correia, N., Silva, J. T., Mateus, M., Silva, J. L. (2023). Scenedesmus rubescens heterotrophic production strategies for added value biomass. Mar. Drugs, 21, 411. https://doi.org/10.3390/md21070411

Gordalina, M., Pinheiro, H. M., Mateus, M., da Fonseca, M.M.R., Cesário, M. T.* (2021). Macroalgae as protein sources—A review on protein bioactivity, extraction, purification and characterization. Appl. Sci.-Basel, 11, 7969. https://doi.org/10.3390/app11177969

Grilo, A. L., Mateus, M., Aires-Barros, M. R., Azevedo, A. M. (2017). Monoclonal antibodies production platforms: An opportunity study of a non-protein-A chromatographic platform based on process economics. Biotechnol. J., 12, 1700260. https://doi.org/10.1002/biot.201700260

Rauta, P. R., Nayak, B., Monteiro, G. A., Mateus, M. (2017). Design and characterization of plasmids encoding antigenic peptides of Aha1 from Aeromonas hydrophila as prospective fish vacines. J. Biotechnol., 241, 116–126. https://doi.org/10.1016/j.jbiotec.2016.11.019

Pereira, L. R., Prazeres, D. M. F., Mateus, M. (2010). Hydrophobic interaction membrane chromatography for plasmid DNA purification: Design and optimization. J. Sep. Sci., 33, 1175–1184. https://doi.org/10.1002/jssc.200900844

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Marília Mateus