Maria Margarida Diogo

associate professor

ABF-4341-2020

Web of Science profile

iBB Group: scerg

margarida.diogo@tecnico.ulisboa.pt

Expertise: Human induced pluripotent stem cells, differentiation, brain organoids and assembloids, neurodevelopmental diseases, heart organoids

Short Bio:

Margarida Diogo finished her PhD in Biotechnology at IST in 2004. She is an Associate Professor at the Department of Bioengineering of IST, lecturing among others the courses “Cell and Tissue Engineering” and “Stem Cell Bioengineering”. She is senior researcher at the Stem Cell Engineering Research Group of iBB, leading the Focus Area of Biology and Engineering of Pluripotent Stem Cells. Her research activities are focused on the development of advanced neural and cardiac tissue models from human pluripotent stem cells and their applications for disease modeling, drug screening and toxicology assays.

Research Focus:

Development of 3D advanced models of human tissues from human pluripotent stem cells and their applications for disease modeling and drug testing

EURAS – EUropean network for neurodevelopmental RASopathies, Collaborative Project funded by HORIZON-HLTH-2022-DISEASE-06-04: Development of new effective therapies for rare diseases. Margarida Diogo is WP Leader and PI/coordinator at iBB. https://www.euras-project.eu/
Mini-Hearts: Organoid Engineering for Production of 3D Cardiovascular Microtissues from Human Induced Pluripotent Stem Cells for Cardiotoxicity Assays (PTDC/EMD-TLM/29728/2017), Maria Margarida Diogo is the PI.

Tenreiro, M. F., Branco, M. A., Cotovio, J. P., Cabral, J. M. S., Fernandes, T. G., Diogo, M. M., (2023). Advancing organoid design through co-emergence, assembly, and bioengineering. Trends in Biotechnology, 41(923). https://doi.org/10.1016/j.tibtech.2022.12.021

Branco, M. A., Dias, T. P., Cabral, J. M. S., Pinto-do-Ó, P., Diogo, M. M. (2022). Human multilineage pro-epicardium/foregut organoids support the development of an epicardium/myocardium organoid. Nature Communications, 13 (6981). https://doi.org/10.1038/s41467-022-34730-7

Gomes, A. R., Fernandes, T. G., Vaz, S. H., Silva, T. P., Bekman, E. P, Xapelli, S., Duarte, S., Ghazvini, M., Gribnau, J., Muotri, A. R., Trujillo, C. A., Sebastião, A. M., Cabral, J. M. S., Diogo, M. M. (2020). Modelling Rett syndrome with human patient-specific forebrain organoids. Frontiers in Cell and Developmental Biology, 8 (610427). https://doi.org/10.3389/fcell.2020.610427

Silva, T. P., Bekman, E. P., Fernandes, T. G., Vaz, S. H., Rodrigues, C. A. V., Diogo, M. M., Cabral, J. M. S., Carmo-Fonseca, M. (2020). Maturation of Human Pluripotent Stem Cell-Derived Cerebellar Neurons in the Absence of Co-culture. Frontiers in Bioengineering and Biotechnology, 8(70). https://doi.org/10.3389/fbioe.2020.00070

Branco, M. A., Cotovio, J. P., Rodrigues, C. A. V., Vaz, S. H., Fernandes, T. G., Moreira, L. M., Cabral, J. M. S., Diogo, M. M. (2019). Transcriptomic analysis of 3D Cardiac Differentiation of Human Induced Pluripotent Stem Cells Reveals Faster Cardiomyocyte Maturation Compared to 2D Culture. Scientific Reports, 9 (9229). https://doi.org/10.1038/s41598-019-45047-9

https://fenix.tecnico.ulisboa.pt/homepage/ist24804

iBB People

Maria Margarida Diogo