Manuel Prieto

Full professor, retired professor

N-4448-2013

Web of Science profile

iBB Group: bsirg

manuel.prieto@tecnico.ulisboa.pt

Expertise: Time-resolved fluorescence; FRET; Fluorescence anisotropy; Spectroscopy; Structural Biology

Short Bio:

MP is Full Professor and President of IUPAB (International Union of Pure and Applied Biophysics (http://iupab.org/). The work obtained international recognition, namely on the application of state-of-the art fluorescence methodologies, both in ensemble average and under the microscope, allowing to retrieve topological and dynamic information on biological systems. Supervised 28 PhD students, was the founder of the Portuguese Biophysical Society, and has a strong record of participation in international scientific organizations: Council of LAFeBS; Science Europe- Sci. Committee; FEBS Publications Committee; Initiative for Science in Europe; UNESCO Chair of Biophysics (Argentina); President of EBSA (European Biophysical Societies' Association).

Research Focus:

Molecular and Cell Biophysics: membrane biophysics, lipid phase diagrams, detection and study of membrane nanodomains, lipid-protein/peptide and lipid-DNA interaction, amyloid fiber formation, ion channels.

LipReleaseTau – “The role of the plasma membrane in the unconventional secretion of tau: insights into the progression of tauopathies”, FCT (2022.01454.PTDC).
https://sciproj.ptcris.pt/175719PRJ; Co-PI

Morán-Lalangui, M., et al. (2024, January). Exploring Protein-Protein Interactions and Oligomerization State of Pulmonary Surfactant Protein C (SP-C) through FRET and Fluorescence Self-Quenching. Protein Sci. 2024;33:e4835. https://doi.org/10.1002/pro.4835

Ventura, et al. (2023, September). Cell lipid droplet heterogeneity and altered biophysical properties induced by cell stress and metabolic imbalance. BBA – Mol. Cell Biol. Lipids 1868, 159347
https://doi.org/10.1016/j.bbalip.2023.159347

Scanavachi, G. et al. (2021, August). Lipid hydroperoxide compromises the membrane structure organization and softens bending rigidity. Langmuir, 37, 33, 9952. https://doi.org/10.1021/acs.langmuir.1c00830

de Almeida, R. F. M.et al. (2003, October). Sphingomyelin/ Phosphatidylcholine/ Cholesterol phase diagram: Boundaries and composition of raft structures. Biophys. J. 85 (4): 2406-2416 doi: 10.1016/s0006-3495(03)74664-5

de Almeida, R. F. M. et al., (2005, March) Lipid rafts have different sizes depending on membrane composition: a time-resolved fluorescence resonance energy transfer study. J. Mol. Biol. 346: 1109-1120 doi:10.1016/j.jmb.2004.12.026

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Manuel Prieto