João Carlos Silva

Collaborating researcher

AAO-6553-2020

Web of Science profile

iBB Group: scerg

joao.f.da.silva@tecnico.ulisboa.pt

Expertise: Tissue Engineering, Biomaterials, Stem Cells, Osteochondral Regeneration, Bioreactors

Short Bio:

João Carlos Silva (JCS) is currently a Marie Skłodowska–Curie Action (MSCA) Postdoctoral Fellow at Politecnico di Torino (Italy) and an Invited Research Associate at SCERG-iBB. JCS received his PhD in Bioengineering – Cell Therapies and Regenerative Medicine in 2019 from Instituto Superior Técnico–Universidade de Lisboa and his MSc in Biomedical Engineering in 2013 from the same institution. During his PhD, JCS worked as a visiting researcher at the Rensselaer Polytechnic Institute (NY-USA) under the guidance of Prof. Robert J. Linhardt (2017-2018). He also worked one year as a research assistant in 3B’s Research Group – University of Minho. João C. Silva is author/co-author of 43 original articles and 17-indexed conference abstracts (h-index of 16, >1130 citations) published in international peer-reviewed scientific journals, 1 book chapter and 1 granted patent, and presented his work in over 40 international scientific conference meetings (27 poster and 30 oral presentations).

Research Focus:

i) Tailoring biomaterials structure and composition to mimic stem cell and tissue microenvironments; ii) Development of novel bio-inspired, biomimetic and “smart” material-based strategies for regenerative medicine and cellular agriculture applications; iii) Design and prototyping of bioreactor devices for the fabrication of tissue-engineered constructs under controlled “in vivo-like” biophysical stimulation.

“SYNERGIES: Smart bioreactor-based platform for the multi-phYsical stimulatioN of Engineered osteochondRal tissues towards functional reGeneratIon and advanced diseasE modelS” (Role: Main Researcher – Marie Skłodowska-Curie Action (MSCA) Postdoctoral Fellow, Project Nº 101155027) / (Funding: 188.590,08 €) / https://cordis.europa.eu/project/id/101155027. Funding agency: Horizon Europe, HORIZON-MSCA-2023-PF-01 – European Union.

“InSilico4OCReg: In silico models guiding in vitro biophysical stimulation of biomimetic hierarchical scaffolds: a computational modelling approach towards functional osteochondral regeneration” (Role: Principal Investigator) / (Funding: 250.000 €) REF: PTDC/EME-SIS/0838/2021. Funding agency: Fundação para a Ciência e Tecnologia (FCT) – Portugal.

“OptiBioscaffold: Stimuli optimization in bi-tissue scaffolds: from mathematical and computational modelling to experimental validation” (Funding: 249.996,07 €) REF: PTDC/EME-SIS/4446/2020. Funding agency: FCT – Portugal.

“DentalBioMatrix: Exploiting the power of decellularized extracellular matrix to fabricate hierarchical biomimetic scaffolds to regenerate functional periodontal tissues” (Funding: 249.536,47 €) REF: PTDC/BTM-BTM/3538/2020. Funding agency: FCT – Portugal.

“Stimuli2BioScaffolds: Stimuli optimization for BioScaffolds – from numerical modelling to in vitro tests” / (Funding: 240.000 €) REF: PTDC/EME-SIS/32554/2017. Funding agency: FCT – Portugal.

Silva, J. C., Marcelino, P., Meneses, J., Barbosa, F., Moura, C. S., Marques, A. C., Cabral, J. M. S., Pascoal-Faria, P., Alves, N., Morgado, J., Ferreira, F. C., & Garrudo, F. F. F. (2024). Synergy between 3D-extruded electroconductive scaffolds and electrical stimulation to improve bone tissue engineering strategies. Journal of Materials Chemistry B, 12(11), 2771–2794. https://doi.org/10.1039/D3TB02673F

Barbosa, F., Garrudo, F.F.F., Marques, A.C., Cabral, J.M.S., Morgado, J.M.F., Ferreira, F.C. & Silva, J.C. (2023). Novel Electroactive Mineralized Polyacrylonitrile/PEDOT:PSS Electrospun Nanofibers for Bone Repair Applications. International Journal of Molecular Sciences, 24(17), 13203. https://doi.org/10.3390/ijms241713203

Barbosa, F., Garrudo, F.F.F., Alberte, P.S., Resina, L., Carvalho, M.S., Jain, A., Marques, A.C., Estrany, F., Rawson, F.J., Aléman, C., Ferreira, F.C. & Silva, J.C. (2023). Hydroxyapatite-Filled Osteoconductive and Piezoelectric Nanofibers for Bone Tissue Engineering. Science and Technology of Advanced Materials, 24(1), 2242242. https://doi.org/10.1080/14686996.2023.2242242

Silva, J.C., Udangawa, R.N., Chen, J., Mancinelli, C.D., Garrudo, F.F.F., Mikael, P.E., Cabral, J.M.S., Ferreira, F.C. & Linhardt, R.J. (2020). Kartogenin-loaded coaxial PGS/PCL aligned nanofibers for cartilage tissue engineering. Materials Science and Engineering: C, 107, 110291. https://doi.org/10.1016/j.msec.2019.110291

Silva, J.C., Carvalho, M.S., Udangawa, R.N., Moura, C.S., Cabral, J.M.S., da Silva, C.L., Ferreira, F.C., Vashishth, D. & Linhardt, R.J. (2020). Extracellular matrix decorated polycaprolactone scaffolds for improved mesenchymal stem/stromal cell osteogenesis towards a patient-tailored bone tissue engineering approach. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 108(5), 2153-2166. https://doi.org/10.1002/jbm.b.34554

Silva, J.C., Moura, C.S., Borrecho, G., Alves de Matos, A.P., da Silva, C.L., Cabral, J.M.S., Bártolo, P.J., Linhardt, R.J. & Ferreira, F.C. (2020). Extruded bioreactor perfusion culture supports the chondrogenic differentiation of human mesenchymal stem/stromal cells in 3D porous poly (ε-caprolactone) scaffolds. Biotechnology Journal, 15(2), 1900079. https://doi.org/10.1002/biot.201900078

iBB People

João Carlos Silva