Joana Feliciano

assistant researcher

K-1473-2016

iBB Group: bsrg

joana.feliciano@tecnico.ulisboa.pt

Expertise: RNA binding proteins (RBPs), noncoding RNAs, bacterial extracelular vesicles, RNA interactome, host-pathogen interaction

Short Bio:

Joana Feliciano is a researcher dedicated to understand noncoding RNA functions and RNA-binding proteins in bacterial pathogens. Completed a Master in Applied Microbiology (Faculty Sciences ULisboa, 2011) and obtained a PhD degree in Biotechnology and Biosciences (IST, 2017), including a two-year period in the laboratory Bacterial Virulence and Chronic Infections (UMontpellier) exploring zebrafish embryos as an infection model. The expertise in the field was reinforced by the international experience as visiting researcher in RNA biology group (UWürzburg) and in Leo Eberl’s group (UZurich), namely in integrative OMICs approaches (RNomics and Interactomics) and in production and isolation of bacterial extracellular vesicles.

ORCID

SCOPUS

CIÊNCIA VITAE

Research Focus:

Posttranscriptional gene regulation of bacterial virulence and antibiotic resistance. Understanding the regulatory functions of small noncoding RNAs in host-pathogen interactions.

Are non-coding RNAs contained in Burkholderia cepacia complex extracellular vesicles used to manipulate the host's immune response? (2022.07091.PTDC)
CNCVir – The coding and noncoding virulome of Burkholderia cenocepacia (PTDC/BIA-MIC/1615/2014),
https://app.dimensions.ai/details/grant/grant.4681493

Exploitation of immunogenic proteins of the Burkholderia cepacia complex to design new diagnostic and therapeutic strategies (PTDC/BBB-BIO/1958/2012),
https://app.dimensions.ai/details/grant/grant.3534266

RNomics-Bcc: RNomics studies to identify small non-coding RNAs of Burkholderia cepacia complex involved in host-pathogen interactions (PTDC/BIA-MIC/119091/2010),
https://app.dimensions.ai/details/grant/grant.3529226

Pita, T., Feliciano, J. R., & Leitão, J. H. (2023). Identification of Burkholderia cenocepacia non-coding RNAs expressed during Caenorhabditis elegans infection. Applied microbiology and biotechnology, 107(11), 3653–3671. https://doi.org/10.1007/s00253-023-12530-3

Feliciano, J. R., Seixas, A. M. M., Pita, T., & Leitão, J. H. (2020). Comparative Genomics and Evolutionary Analysis of RNA-Binding Proteins of Burkholderia cenocepacia J2315 and Other Members of the B. cepacia Complex. Genes, 11(2), 231. https://doi.org/10.3390/genes11020231

Gomes, M. C., Tasrini, Y., Subramoni, S., Agnoli, K., Feliciano, J. R., Eberl, L., Sokol, P., O'Callaghan, D., & Vergunst, A. C. (2018). The afc antifungal activity cluster, which is under tight regulatory control of ShvR, is essential for transition from intracellular persistence of Burkholderia cenocepacia to acute pro-inflammatory infection. PLoS pathogens, 14(12), e1007473. https://doi.org/10.1371/journal.ppat.1007473

Pita, T., Feliciano, J. R., & Leitão, J. H. (2018). Small Noncoding Regulatory RNAs from Pseudomonas aeruginosa and Burkholderia cepacia Complex. International journal of molecular sciences, 19(12), 3759. https://doi.org/10.3390/ijms19123759

Mesureur, J., Feliciano, J. R., Wagner, N., Gomes, M. C., Zhang, L., Blanco-Gonzalez, M., van der Vaart, M., O'Callaghan, D., Meijer, A. H., & Vergunst, A. C. (2017). Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation. PLoS pathogens, 13(6), e1006437. https://doi.org/10.1371/journal.ppat.1006437

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Joana Feliciano