Dalila Mil-Homens

assistant researcher

F-7900-2014

Web of Science profile

iBB Group: bsrg

dalilamil-homens@tecnico.ulisboa.pt

Expertise: Burkholderia cenocepacia, Type V secretion system, Adhesion, Galleria mellonella, Infection model

Short Bio:

Dalila Mil-Homens is a dedicated researcher in Bioengineering and Biosciences, quietly making valuable contributions to the field. With a MSc (2007) and a PhD (2012) in Biotechnology from Instituto Superior Técnico, her research has focused on unveiling the functions played by some Burkholderia cenocepacia type V secretion system proteins, in host-pathogen interactions and virulence. With multiple established collaborations, Dalila is a specialist on Galleria mellonella, an alternative non-mammal infection model.

ORCID

SCOPUS

CIÊNCIA VITAE

Research Focus:

Investigation on Burkholderia cenocepacia host-pathogen interactions and Galleria mellonella infection model.

DENDRICARE – Next generation antibiofilm agents: Multivalent dendrimers with antimicrobial and biofilm disruption activity (2022.03627.PTDC)
TRAMONTE – Valuing the biological resources of the northern interior: Tramazeira as a case-study (PD21-000013)

PHARMAPITOX – Development of an innovative collector and protocol for apitoxin purification for use in the pharmaceutical industries. (LISBOA-01-0247-FEDER-113540) https://portal3.ipb.pt/uploads/apoioinvestigacao/fichas_projeto/2022/Ficha_projeto_consorcio_pharmapitox.pdf

DeathTrigger – Activating dormant bacteria with phage-derived proteins to enhance antibiotic efficacy (PTDC/BIA-MIC/2312/2020) https://www.ceb.uminho.pt/Projects/Details/6215

Ure-lockers – Urease Next-Generation Inhibition Therapy (PTDC/MED-QUI/3542/2020) https://www.spq.pt/magazines/BSPQuimica/695/article/30002362/pdf

Martins, C., Piontkivska, D., Mil-Homens, D., Guedes, P., Jorge, J.M.P., Brinco, J., Bárria, C., Santos, A.C.F., Barras, R., Arraiano, C., Fialho, A., Goldman, G.H., & Silva Pereira, C. (2023 June 7). Increased Production of Pathogenic, Airborne Fungal Spores upon Exposure of a Soil Mycobiota to Chlorinated Aromatic Hydrocarbon Pollutants. Microbiology Spectrum, e0066723. https://doi.org/10.1128%2Fspectrum.00667-23

Pinto, S.N., Mil-Homens, D., Pires, R.F., Alves, M.M., Serafim, G., Martinho, N., Melo, M., Fialho, A.M., & Bonifácio, V.D.B. (2022, September 13). Core-shell polycationic polyurea pharmadendrimers: new-generation of sustainable broad-spectrum antibiotics and antifungals. Biomaterials Science, 10(18):5197-5207. https://doi.org/10.1039/D2BM00679K

Bárria, C., Mil-Homens, D., Pinto, S.N., Fialho, A.M., Arraiano, C.M., & Domingues, S. (2022, January 29). RNase R, A new virulence determinant of Streptococcus pneumoniae. Microorganism, 10(2):317. https://doi.org/10.3390/microorganisms10020317
Pimenta, A.I., Bernardes, N., Alves, M.M., Mil-Homens, D., Fialho, A.M. (2021, March 11) Burkholderia cenocepacia transcriptome during the early contacts with giant plasma membrane vesicles derived from live bronchial epithelial cells. Scientific Reports, 11(1):5624. https://doi.org/10.1038%2Fs41598-021-85222-5

Pimenta, A.I., Kilcoyne, M., Bernardes, N., Mil-Homens, D., Joshi, L., & Fialho, A.M. Burkholderia cenocepacia BCAM2418-induced antibody inhibits bacterial adhesion, confers protection to infection and enables identification of host glycans as adhesin targets. Cell Microbiology, 2021_a Aug;23(8):e13340. doi: 10.1111/cmi.13340. (Contributions: conceptualization, methodology, writing – reviewing and editing) (Q2; IF: 4.115, C:3)

Mil-Homens, D., Pinto, S.N., Matos RG, Arraiano C, Fialho AM. Burkholderia cenocepacia K56-2 trimeric autotransporter adhesin BcaA binds TNFR1 and contributes to induce airway inflammation. Cell Microbiol. 2017 Apr;19(4). doi: 10.1111/cmi.12677. Epub 2016 Oct 27. PMID: 27684048.

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Dalila Mil-Homens