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  • Research
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      • Stem Cell Engineering
    • Publications
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      • National Projects
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Dalila Mil-Homens

Dalila Mil-Homens

assistant researcher
F-7900-2014
Web of Science profile
iBB Group: bsrg
dalilamil-homens@tecnico.ulisboa.pt
Email
Expertise: Burkholderia cenocepacia, Type V secretion system, Adhesion, Galleria mellonella, Infection model
Short Bio:
Dalila Mil-Homens is a dedicated researcher in Bioengineering and Biosciences, quietly making valuable contributions to the field. With a MSc (2007) and a PhD (2012) in Biotechnology from Instituto Superior Técnico, her research has focused on unveiling the functions played by some Burkholderia cenocepacia type V secretion system proteins, in host-pathogen interactions and virulence. With multiple established collaborations, Dalila is a specialist on Galleria mellonella, an alternative non-mammal infection model.
ORCID
SCOPUS
CIÊNCIA VITAE
Research Focus:
Investigation on Burkholderia cenocepacia host-pathogen interactions and Galleria mellonella infection model.

DENDRICARE – Next generation antibiofilm agents: Multivalent dendrimers with antimicrobial and biofilm disruption activity (2022.03627.PTDC)
TRAMONTE – Valuing the biological resources of the northern interior: Tramazeira as a case-study (PD21-000013)

PHARMAPITOX – Development of an innovative collector and protocol for apitoxin purification for use in the pharmaceutical industries. (LISBOA-01-0247-FEDER-113540) https://portal3.ipb.pt/uploads/apoioinvestigacao/fichas_projeto/2022/Ficha_projeto_consorcio_pharmapitox.pdf

DeathTrigger – Activating dormant bacteria with phage-derived proteins to enhance antibiotic efficacy (PTDC/BIA-MIC/2312/2020) https://www.ceb.uminho.pt/Projects/Details/6215

Ure-lockers – Urease Next-Generation Inhibition Therapy (PTDC/MED-QUI/3542/2020) https://www.spq.pt/magazines/BSPQuimica/695/article/30002362/pdf

Martins, C., Piontkivska, D., Mil-Homens, D., Guedes, P., Jorge, J.M.P., Brinco, J., Bárria, C., Santos, A.C.F., Barras, R., Arraiano, C., Fialho, A., Goldman, G.H., & Silva Pereira, C. (2023 June 7). Increased Production of Pathogenic, Airborne Fungal Spores upon Exposure of a Soil Mycobiota to Chlorinated Aromatic Hydrocarbon Pollutants. Microbiology Spectrum, e0066723. https://doi.org/10.1128%2Fspectrum.00667-23

Pinto, S.N., Mil-Homens, D., Pires, R.F., Alves, M.M., Serafim, G., Martinho, N., Melo, M., Fialho, A.M., & Bonifácio, V.D.B. (2022, September 13). Core-shell polycationic polyurea pharmadendrimers: new-generation of sustainable broad-spectrum antibiotics and antifungals. Biomaterials Science, 10(18):5197-5207. https://doi.org/10.1039/D2BM00679K

Bárria, C., Mil-Homens, D., Pinto, S.N., Fialho, A.M., Arraiano, C.M., & Domingues, S. (2022, January 29). RNase R, A new virulence determinant of Streptococcus pneumoniae. Microorganism, 10(2):317. https://doi.org/10.3390/microorganisms10020317
Pimenta, A.I., Bernardes, N., Alves, M.M., Mil-Homens, D., Fialho, A.M. (2021, March 11) Burkholderia cenocepacia transcriptome during the early contacts with giant plasma membrane vesicles derived from live bronchial epithelial cells. Scientific Reports, 11(1):5624. https://doi.org/10.1038%2Fs41598-021-85222-5

Pimenta, A.I., Kilcoyne, M., Bernardes, N., Mil-Homens, D., Joshi, L., & Fialho, A.M. Burkholderia cenocepacia BCAM2418-induced antibody inhibits bacterial adhesion, confers protection to infection and enables identification of host glycans as adhesin targets. Cell Microbiology, 2021_a Aug;23(8):e13340. doi: 10.1111/cmi.13340. (Contributions: conceptualization, methodology, writing – reviewing and editing) (Q2; IF: 4.115, C:3)

Mil-Homens, D., Pinto, S.N., Matos RG, Arraiano C, Fialho AM. Burkholderia cenocepacia K56-2 trimeric autotransporter adhesin BcaA binds TNFR1 and contributes to induce airway inflammation. Cell Microbiol. 2017 Apr;19(4). doi: 10.1111/cmi.12677. Epub 2016 Oct 27. PMID: 27684048.

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iBB aims to excel in research and advanced education in biotechnology, by responding to the challenge of exploring innovative approaches to key scientific and technological questions in Biosciences and Bioengineering and of transforming scientific knowledge into tangible innovation.

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iBB Funding: FCT / Portuguese Republic / EU / Portugal 2020 / PRR

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