Cláudia Lobato da Silva

associate professor

K-6104-2012

Web of Science profile

iBB Group: scerg

claudia_lobato@tecnico.ulisboa.pt

Expertise: Stem Cell

Short Bio:

Cláudia Lobato da Silva received a Diploma in Chemical Engineering (Biotechnology), Instituto Superior Técnico (IST), Technical University of Lisboa (Universidade Técnica de Lisboa, UTL), Portugal, in 2001, and got a Ph.D. in Biotechnology in 2006 at IST-UTL in collaboration with the University of Nevada, Reno, USA. Presently, she is Associate Professor at the Department of Bioengineering, IST, Universidade de Lisboa, Lisboa. Cláudia Lobato da Silva’s research interests include expansion of human stem cells, cellular therapies with human stem cells, genetic engineering of human stem cells, and bioreactors for stem cell culture and production of extracellular vesicles.

ORCID

SCOPUS

CIÊNCIA VITAE

Research Focus:

Development and Manufacturing of Cell-based Therapies

UROPRINT-Urinary bladder bioprinting for fully autologous transplantation (H2020-FETOPEN-964883, https://www.uroprint.eu/

AMELIE-Anchored Muscle cELls for IncontinencE (H2020-SC1-BHC-2018-2020-874807), https://amelie-project.eu/

Fernandes-Platzgummer A, Cunha R, Morini S, Carvalho M, Moreno-Cid J, García C, Cabral JMS, da Silva CL. (2023) Optimized operation of a controlled stirred tank reactor system for the production of mesenchymal stromal cells and their extracellular vesicles. Biotechnol Bioeng. 120(9):2742-2755 https://doi: 10.1002/bit.28449

Bucar S, Branco ADM, Mata MF, Milhano JC, Caramalho Í, Cabral JMS, Fernandes-Platzgummer A, da Silva CL (2021) Influence of the mesenchymal stromal cell source on the hematopoietic supportive capacity of umbilical cord blood-derived CD34+-enriched cells Stem Cell Res Ther. 12(1):399 https://doi: 10.1186/s13287-021-02474-8.

de Almeida Fuzeta M, Bernardes N, (…) da Silva CL. (2020) .Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System. Front Cell Dev Biol 3;8:553444 https://doi.org/10.3389/fcell.2020.553444

Branco A, Bucar S, Moura-Sampaio J, Lilaia C, Cabral JMS, Fernandes Platzgummer A, da Silva CL (2020) Tailored Cytokine Optimization for ex vivo Culture Platforms Targeting the Expansion of Human Hematopoietic Stem/Progenitor Cells Front Bioeng Biotechnol 25;8:573282 https://doi: 10.3389/fbioe.2020.573282

Mizukami A, Fernandes-Platzgummer A, Carmelo JG, Swiech K, Covas DT, Cabral JM, da Silva CL (2016) Stirred tank bioreactor culture combined with serum-/xenogeneic-free culture medium enables an efficient expansion of umbilical cord-derived mesenchymal stem/stromal cells Biotechnol J 11(8):1048-59 https://doi: 10.1002/biot.201500532

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Cláudia Lobato da Silva