Cecília Calado

Researcher, Coordinating Professor with Aggregation

E-2102-2014

Web of Science profile

iBB Group: 2brg

cecilia.calado@isel.pt

Expertise: PAT- process analytical technology applied to bioprocesses, Drugs discovery & development, Metabolomics

Short Bio:

Cecília R.C. Calado is a Researcher in Bioengineering and Biosciences, presents a BSc in Biochemistry (5 years university), and a MSc and a PhD in Biotechnology and Aggregation in Biochemistry. She associates analytical techniques to acquire the molecular fingerprint of biological systems, with machine learning algorithms, to: • develop monitoring techniques of bioprocesses, in situ and in real time or at-line high-throughput, as included in PAT- process analytical technologies. • develop platforms for drugs discovery and development, including antibiotics and vaccines. • discover biomarkers for medical diagnosis and prognosis.

Research Focus:

Bioprocess engineering, including modelling complex biological systems & development of monitoring techniques. Discovery and development of drugs and vaccines Discovery of medical biomarkers.

R-DICIP – Rapid Diagnosis of Infections in Critically ill patients, IDI&CA/IPL/2024/NephoMD/ISEL

NephroMD- On-skin diagnostic device for kidney chronic disease management based on sweat analysis, IDI&CA/IPL/2020/NephoMD/ISEL.

DrugsPlatf – A Disruptive Antibiotics Discovery Platform – Based on the Rapid Identification of the Mechanism of Action and the Biological Target, IDI&CA/IPL/2017/DrugsPlatf/ISEL.

KC Sales, F Rosa, PN Sampaio, LP Fonseca, MB Lopes, CRC Calado (2015). In situ near-infrared (NIR) versus high-throughput mid-infrared (MIR) spectroscopy to monitor biopharmaceuticals production. Appl Spectrosc; 69(6):760-72. doi: 10.1366/14-07588

BR Cunha, SM Aleixo, LP Fonseca, CRC Calado (2021). Fast identification of off-target liabilities in early antibiotic discovery with Fourier-transform infrared spectroscopy. Biotechnol Bioeng.; 118 (11): 4465-4476. doi: 10.1002/bit.27915

T Fonseca, C Von Rekowski, R Araújo, MC Oliveira, G Justino, CRC Calado (2023). The Impact of Serum extraction protocol on metabolomic profiling using UPLC-MS/MS and FTIR spectroscopy. ACS Omega; 8(23): 20755–20766. doi:10.1021/acsomega.3c01370

A Viegas, R Araujo, L Ramalhete, CP Von Rekowski, TAH Fonseca, L Bento, CR.C. Calado (2024). Discovery of Delirium Biomarkers through Minimally Invasive Serum Molecular Fingerprinting. Metabolites. 2024; 14:301. doi:10.3390/metabo14060301

Caldeira, T.A.H. Fonseca. L. N´Dembro, R. Araújo, CP von Rekowski, PNS Sampaio, CTC Calado (2024). A new method for a rapid and high-throughput comparison of molecular profiles and biological activity of phytoextracts. Biotechnol. Bioeng. Doi:10.1002/bit.28739

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Cecília Calado