Arsenio Fialho

Arsenio M. Fialho

full professor

A-6246-2008

Web of Science profile

iBB Group: bsrg

afialho@tecnico.ulisboa.pt

Expertise: Molecular Microbiology, Pathogenomics, Microbial-based therapy of cancer

Short Bio:

Arsénio M Fialho, is professor of Biochemistry and Molecular and Cellular Biology in the Bioengineering Department of Instituto Superior Técnico, University of Lisbon and principal investigator in the Biological Sciences Research Group, Institute for Bioengineering and Biosciences (iBB) and Institute for Health and Bioeconomy (i4HB). His current research interests in the area of Molecular and Cellular Microbiology center on the studies of pathogenic bacteria on two different fronts: i) study the phenomena of bacterial adhesion to host cells and its significance in pathogenesis; ii) use pathogenic bacteria as reservoirs of potential therapeutic products to treat various types of cancer.

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Research Focus:

Studies of pathogenic bacteria on two fronts: the phenomena of bacterial adhesion to host cells; use bacteria as reservoirs of therapeutic products to treat cancer

Cell penetrating p28 peptide-mediated delivery of nanomedicines for cancer treatment. Contract: PTDC/BTM-SAL/30034/2017
Virulence-associated Trimeric Autotransporter Adhesins from Burkholderia cenocepacia: functional, biophysical and structural characterization. Contract: PTDC/BIA-MIC/118386/2010

Bacterial protein azurin as a new candidate drug to treat untreatable breast cancers. Contract: PTDC/EBB-BIO/100326/2008

R Estevens, D Mil-Homens, AM Fialho (2023). In-Silico Analysis Highlights the Existence in Members of Burkholderia cepacia Complex of a New Class of Adhesins Possessing Collagen-like Domains. Microorganisms 11 (5), 1118
https://doi.org/10.3390/microorganisms11051118

Garizo AR, Coelho LF, Pinto S, Dias TP, Fernandes F, Bernardes N, Fialho AM (2021). The Azurin-Derived Peptide CT-p19LC Exhibits Membrane-Active Properties and Induces Cancer Cell Death. Biomedicines,10;9(9):1194
https://doi.org/10.3390/biomedicines9091194

Garizo AR, Castro F, Martins C, Almeida A, Dias TP, Fernardes F, Barrias CC, Bernardes N, Fialho AM*, Sarmento B* (2021) p28-functionalized PLGA nanoparticles loaded with gefitinib reduce tumor burden and metastases formation on lung cancer. Journal of Controlled Release, 337:329-342
https://doi.org/10.1016/j.jconrel.2021.07.035

Pimenta AI, Kilcoyne M, Bernardes N, Mil-Homens D, Joshi L, Fialho AM (2021) Burkholderia cenocepacia BCAM2418-induced antibody inhibits bacterial adhesion, confers protection to infection and enables identification of host glycans as adhesin targets” Cellular Microbiology, e13340,
doi: 10.1111/cmi.13340

Pimenta AI, Bernardes N, Alves MM, Mil-Homens D, Fialho AM (2021) Burkholderia cenocepacia transcriptome during the early contacts with giant plasma membrane vesicles derived from live bronchial epithelial cells. Scientific Reports
doi.org/10.1038/s41598-021-85222-5, 2021

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Arsenio M. Fialho