Ana Platzgummer

Ana Fernandes Platzgummer

assistant professor

F-1685-2011

Web of Science profile

iBB Group: scerg

ana.fernandes@tecnico.ulisboa.pt

Expertise: Stem cells, Extracellular vesicles, Process development, Bioreactors, and Process monitoring

Short Bio:

Ana Fernandes-Platzgummer (AFP) is an Assistant Professor at the Department of Bioengineering at Instituto Superior Técnico and the principal investigator at the "Smart Bioprocess Design for Cellular and Molecular Therapies LAB" at SCERG-iBB. With a PhD in Bioengineering Systems from the MIT-Portugal Program (2011), AFP research focus on scalable bioprocess engineering for the production of cells and their derivatives. AFP has authored over 50 peer-reviewed publications and raised €0.6M for research since 2016. AFP supervises 4 PhD and 2 master's students. Her work is characterized by interdisciplinary collaboration, focusing on cost-effective, integrated bioprocess solutions for producing cell and cell-derived products.

Research Focus:

Ana Fernandes-Platzgummer research focuses on designing bioprocesses for large-scale production of various cell types and derivatives from different species, including human, porcine, and bovine species.

National (As PI)

NKBOOST – Quality by design-centered platform for the manufacturing of CAR-engineered NK cells and extracellular vesicles for immunotherapy, 2021-24 (FCT ST&ID Project PTDC/EQU-EQU/3708/2021)

EXOPro – Development of a scalable manufacturing process for therapeutic human mesenchymal stem/stromal cell-derived exosomes, 2018-22 (FCT ST&ID Project PTDC/EQU-EQU/31651/2017)

HSCexpand: Design and operation of a prototype packed-bed reactor for the production of hematopoietic stem/progenitor cells,2016-19 (FCT ST&ID Project PTDC/QEQ-EPR/6623/2014)

International (Member of the IST team)

UROPRINT: Urinary bladder bioprinting for fully autologous transplantation, 2021-25, (964883 H2020-FETOPEN-2018-2019-2020-01 European Union) PI: Apostolos Klinakis, Greece

AMELIE: Anchored Muscle cELls for IncontinencE, 2020-25 (H2020-SC1-BHC-2018-2020 European Union) PI: Richard Day, UK

Bandarra-Tavares, H., & Fernandes-Platzgummer, A., da Silva, C.L. (2024). A flexible and scalable platform for the dual production of human mesenchymal stromal cells and derived extracellular vesicles in a dissolvable microcarrier-based stirred culture system. Cytotherapy 11:S1465-3249(24)00088-4. https://doi.org/10.1016/j.jcyt.2024.03.001

Fernandes-Platzgummer, A. & da Silva, C.L. (2023). Optimized operation of a controlled stirred tank reactor system for the production of mesenchymal stromal cells and their extracellular vesicles. Biotechnology and Bioengineering, 120(9):2742-2755. https://doi.org/10.1002/bit.28449

Silva, R.M., & Fernandes-Platzgummer, A. (2023). Anion exchange chromatography-based platform for the scalable purification of extracellular vesicles derived from human mesenchymal stromal cells. Separation and Purification Technology, 310, 123238. https://doi.org/10.1016/j.seppur.2023.123238

Branco, A., & Fernandes-Platzgummer, A. (2023). Hypothermic Preservation of Adipose-Derived Mesenchymal Stromal Cells as a Viable Solution for the Storage and Distribution of Cell Therapy Products. Bioengineering-Basel, 9(12). https://doi.org/10.3390/bioengineering9120805

Branco, A., & Fernandes-Platzgummer, A., da Silva, C.L. (2020). Tailored Cytokine Optimization forex vivoCulture Platforms Targeting the Expansion of Human Hematopoietic Stem/Progenitor Cells. Frontiers in Bioengineering and Biotechnology, 25:8:573282. https://doi.org/10.3389/fbioe.2020.573282

iBB People

Ana Fernandes Platzgummer