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Ana Melo

Ana M. Melo

assistant researcher
Q-6580-2017
Web of Science profile
iBB Group: bsirg
anammelo@tecnico.ulisboa.pt
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Expertise: Intrinsically disordered proteins (IDPs); Single-molecule fluorescence techniques; Neurodegenerative diseases; Lipid-protein interaction; Membrane Biophysics
Short Bio:
Ana M Melo is a CEEC-individual FCT Researcher (since 2019). She has a multidisciplinary background in biochemistry, cell biology and molecular biophysics. Ana M Melo holds a BSc and MSc in Biochemistry (2007 and 2009) from Faculty of Sciences, ULisbon. She obtained her PhD in Chemistry (2014) at IST. She was a Postdoc at Elizabeth Rhoades Lab- first at Yale University and then at University of Pennsylvania (2014 –2017). She returned to IST in Oct 2017 and built the first single-molecule FRET microscope in Portugal. Her lab aims to develop innovative single-molecule approaches to characterize the early-events of protein aggregation.
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Research Focus:
Characterizing the dysfunction and the aggregation-prone structures of intrinsically disordered proteins (IDPs) involved in neurodegeneration, including tau protein (Alzheimer´s disease) and also huntingtin (Huntington’s disease).

PI of LipReleaseTau: The role of the plasma membrane in the unconventional secretion of tau: insights into the progression of tauopathies (2022.01454.PTDC). Funded by FCT-Portugal
Maria de Sousa Award- 2nd edition: Tracking the unconventionally secreted tau species: insights into the progression of tauopathies (PMS 45/2022). Funded by Bial Foundation and Portuguese Medical Association

PI of SingleMolHTTex1: The aggregation-prone structures of Huntingtin exon 1 at the single-molecule level: Influence of membranes and implications in Huntington disease (PTDC/BIA-BFS/30959/2017). Funded by FCT-Portugal

Management Committee Member and co-Leader of Working Group 4 (WG4) of the COST-Action- ML4NGP: Non-globular proteins in the era of Machine Learning (CA21160). European Funding.

Scanavachi, G., Coutinho, A., Fedorov, A. A., Prieto, M., Melo, A. M., & Itri, R. (2021). Lipid Hydroperoxide Compromises the Membrane Structure Organization and Softens Bending Rigidity. Langmuir, 37(33), 9952-9963. https://doi.org/10.1021/acs.langmuir.1c00830

Birol, M., & Melo, A. M. (2019). Untangling the Conformational Polymorphism of Disordered Proteins Associated With Neurodegeneration at the Single-Molecule Level. Front. Mol. Neurosci., 12, 309. https://doi.org/10.3389/fnmol.2019.00309

Melo, A. M., Elbaum-Garfinkle, S., & Rhoades, E. (2017). Insights into tau function and dysfunction through single-molecule fluorescence. Methods in Cell Biology, 141, 27-44. https://doi.org/10.1016/bs.mcb.2017.06.010

Melo, A. M., Coraor, J., Alpha-Cobb, G., Elbaum-Garfinkle, S., Nath, A., & Rhoades, E. (2016). A functional role for intrinsic disorder in the tau-tubulin complex. Proc. Natl. Acad. Sci. U.S.A., 113(50), 14336-14341. https://doi.org/10.1073/pnas.1610137113

Jülich, D., Cobb, G., Melo, A. M., McMillen, P., Lawton, A. K., Mochrie, S. G., Rhoades, E., & Holley, S. A. (2015). Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology. Dev. Cell, 34(1), 33-44. https://doi.org/10.1016/j.devcel.2015.05.005

About

iBB aims to excel in research and advanced education in biotechnology, by responding to the challenge of exploring innovative approaches to key scientific and technological questions in Biosciences and Bioengineering and of transforming scientific knowledge into tangible innovation.

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Técnico Lisboa
Av. Rovisco Pais
1049-001 Lisboa, Portugal

+351 218 419 065
ibb@ibb.pt

Associate Laboratory

Institute for Health and Bioeconomy (i4HB)

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iBB Funding: FCT / Portuguese Republic / EU / Portugal 2020 / PRR

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