Ana Azevedo

associate professor

A-2985-2011

Web of Science profile

iBB Group: berg

a.azevedo@tecnico.ulisboa.pt

Expertise: Downstream processing, Chromatography, Membrane Processes, Liquid-liquid extraction, Biopharmaceuticals

Short Bio:

Ana Azevedo is a senior researcher in biotechnology and bioengineering, holding a degree in Chemical Engineering (1996), a MSc in Biochemistry (1999) and a PhD in Biotechnology (2004), from Instituto Superior Técnico. Her expertise lies in bioprocess engineering, focusing on the optimisation, integration and intensification of bioprocesses through miniaturisation, high throughput screening, and continuous bioprocessing. Her current research interests are on enhancing manufacturing processes for emerging modalities, such as bacteriophages and nucleic acids (pDNA and mRNA), by designing innovative downstream processing strategies. Ana is also involved in various communication and dissemination activities, bridging the gap between the research community and society.

ORCID

SCOPUS

CIÊNCIA VITAE

Research Focus:

Exploring innovative methods to enhance the manufacturing process of biological products through advanced bioprocessing engineering and downstream processing solutions

DIG4BIO – Digitalisation of Biomanufacturing of Plasmids for the Development of Advanced Therapy Modalities (HORIZON-WIDERA-2023-ACCESS-02-01- 101159993)

mRNA – Enabling vaccination by improving the mRNA quality in the manufacturing process (Moderna Global Fellowship/174/012023)

CODOBIO – Continuous Downstream Processing of Bioproducts (H2020-MSCA-ITN-2018- 812909), https://www.codobio.eu

Phage4BacID – Bacteriophages in the diagnosis and prevention of multidrug-resistant infections in Portugal and worldwide (LISBOA-01-0247-FEDER-03303)

PureMab – Multimodal chromatography as an alternative to pure chromatographic modes for the capture and polishing of monoclonal antibodies (PTDC/QEQ-PRS/0286/2014)

Nascimento, A., São Pedro, M. N., Pinto, I. F., Aires-Barros, M. R., & Azevedo, A. M. (2021). Microfluidics as a high-throughput solution for chromatographic process development – The complexity of multimodal chromatography used as a proof of concept. Journal of chromatography. A, 1658, 462618. https://doi.org/10.1016/j.chroma.2021.462618

Javidanbardan, A., Chu, V., Conde, J. P., & Azevedo, A. M. (2022). Microchromatography integrated with impedance sensor for bioprocess optimization: Experimental and numerical study of column efficiency for evaluation of scalability. Journal of chromatography. A, 1661, 462678. https://doi.org/10.1016/j.chroma.2021.462678

Rosa, S. S., Nunes, D., Antunes, L., Prazeres, D. M. F., Marques, M. P. C., & Azevedo, A. M. (2022). Maximizing mRNA vaccine production with Bayesian optimization. Biotechnology and bioengineering, 119(11), 3127–3139. https://doi.org/10.1002/bit.28216

Silva, R. M., Rosa, S. S., Cunha, R., da Silva, C. L., Azevedo, A. M., & Fernandes-Platzgummer, A. (2023). Anion exchange chromatography-based platform for the scalable purification of extracellular vesicles derived from human mesenchymal stromal cells. Sep. Purif. Technol., 310, 123238. https://doi.org/10.1016/j.seppur.2023.123238

Ferreira-Faria, D., Domingos-Moreira, F., Aires-Barros, M. R., Ferreira, A., & Azevedo, A. M. (2023). Continuous precipitation of antibodies using oscillatory flow reactor: A proof of concept. Separation and Purification Technology, 317, 123924. https://doi.org/10.1016/j.seppur.2023.123924

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Ana Azevedo