In a recent study led by the Federal University of São Carlos (UFSCar, Brazil) and CENIMAT | i3N at NOVA School of Science and Technology (Universidade NOVA de Lisboa), iBB researchers Frederico Barbosa and João Carlos Silva contributed to the biological validation of new stimuli-responsive gyroid scaffolds fabricated via sacrificial templating, developed as a promising platform for bone tissue engineering applications.
The results, recently published in Materials Today (Elsevier), demonstrate that the hierarchical scaffold is able to generate electric fields in response to mechanical stimuli. This property enhances cytoskeletal alignment and promotes the osteogenic differentiation of human bone marrow-derived mesenchymal stem/stromal cells (hBMSCs).
Furthermore, by modulating scaffold porosity and adjusting the intensity of ultrasound stimulation, researchers were able to boost metabolic activity, osteogenic gene expression, and mineralization—key processes for enhanced bone regeneration.
This study highlights the potential of advanced bioengineered scaffolds as innovative tools to improve outcomes in regenerative medicine and bone repair.
Link to the publication:https://doi.org/10.1016/j.mattod.2025.06.013