Acronym PWS_Metabolite Title Role of microbial metabolites in regulating hypothalamic pathways involved in feeding behavior Summary

This project investigates the impact of microbial metabolites on appetite regulation and energy balance in individuals with Prader-Willi Syndrome (PWS) through a collaboration with Dr. Lerin’s lab at Fundació Sant Joan de Déu, Spain. By analyzing the effects of probiotic supplementation on the gut microbiome and metabolome in subjects with PWS, the study aims to identify potential biomarkers and therapeutic targets for the disease. Additionally, the project seeks to generate and characterize hypothalamic arcuate nucleus organoids (ARCOs) from stem cells, providing a platform to evaluate the impact of selected metabolites on hypothalamic functioning, thus shedding light on the molecular mechanisms underlying PWS and potential therapeutic interventions

Project webpage Open project webpage Start year 01/01/2023 End year 30/11/2024 ID ID: 1029673 iBB Role partner iBB Budget 10 000,00 € Research Group SCERG PI Simão Rocha Project Partners Fundació Sant Joan de Déu (Coord.) Status Ongoing Funding Foundation for Prader-Willi Research