Acronym NKBoost Title Quality by design-centered platform for the manufacturing of CAR-engineered NK cells and extracellular vesicles for immunotherapy Summary

The main goal of NKBoost is to design and develop a scalable quality-by-design (QbD)-centered manufacturing platform for human CAR-NK cells and their derives extracellular vesicles (EVs). The project seeks to address key challenges, including the precise definition of critical quality attributes (CQAs) for CAR-NK cells/EVs, and the identification of critical process parameters (CPPs) across various stages such as large-scale transduction of NK cells, expansion of CAR-NK cells, EVs production and continuous purification processes.

Project webpage Start year 01/01/2022 End year 31/12/2024 ID PTDC/EQU-EQU/3708/2021 iBB Role Coordinator iBB Budget 234 999,45 € Research Group SCERG PI Ana Fernandes Project Partners ISEL-Instituto Superior de Engenharia de Lisboa Status Ongoing Funding FCT