Vasco Bonifácio in collaboration with the Radiopharmaceutical Sciences group (C2TN – Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico), developed a new methodology for cancer radiodiagnosis.
In this work, polyurea (PURE) dendrimers, a class of biodendrimers, were found to be radioadhesive, an intrinsic characteristic conferred by the spatial configuration of the terminal amine groups present on the surface of the dendrimers.
PURE radiolabeling avoids the use of ligands and bioconjugation chemistry and occurs simply by mixing Technetium-99m and folate conjugated PURE dendrimers, a target chosen for the diagnosis of ovarian cancer. This strategy can also be applied in cancer radiotheranostics.
The work was published in Chem. Commun., a journal from the Royal Society of Chemistry, and was selected as the back cover.
DOI: https://lnkd.in/d-vF8VMw.