iBB https://ibb.tecnico.ulisboa.pt Institute for Bioengineering and Biosciences Fri, 17 Jul 2026 17:39:13 +0000 en-US hourly 1 https://ibb.tecnico.ulisboa.pt/wp-content/uploads/2023/11/cropped-IBB_logo_icon-01-32x32.png iBB https://ibb.tecnico.ulisboa.pt 32 32 IST-Yeasts CC: A Newly Established Culture Collection of Yeasts of Biotechnological Potential, Isolated from Algae-Associated Environments https://ibb.tecnico.ulisboa.pt/ist-yeasts-cc-a-newly-established-culture-collection-of-yeasts-of-biotechnological-potential-isolated-from-algae-associated-environments/ Fri, 17 Jul 2026 17:39:13 +0000 https://ibb.tecnico.ulisboa.pt/?p=15174 We are pleased to share the latest iBB article, “IST-Yeasts CC: A Newly Established Culture Collection of Yeasts of Biotechnological Potential, Isolated from Algae-Associated Environments”, published in the Special Issue “Bioengineering Approaches to Microalgae-Based Systems” of the journal Bioengineering.

This work introduces the IST-Yeasts Culture Collection (IST-Yeasts CC) – a new biological resource assembled and preserved over the past few years by Isabel Sá-Correia‘s research group, with the key involvement of Madalena Matos and Mónica Fernandes, at the Biological Sciences Research Group, iBB-Institute for Bioengineering and Biosciences, Departamento de Bioengenharia, Instituto Superior Técnico (University of Lisbon). The collection is dedicated to non-conventional “blue” yeasts isolated from (micro)algae-associated environments in Portugal.

It currently holds 115 yeast strains, mostly from the phylum Basidiomycota (92%), with a strong representation of the genus Rhodotorula, alongside species from Cystobasidium, Vishniacozyma, Moesziomyces, Sporobolomyces, Naganishia, and Ascomycota members such as Meyerozyma, Yamadazyma, and Cyberlindnera.

Initial functional screening revealed that these strains can produce carotenoids, lipids, riboflavin, biosurfactants, bioemulsifiers, and auxins, as well as growing on a wide range of carbon sources.

These characteristics highlight their biotechnological potential within the circular bioeconomy and sustainable bioprocesses, positioning them as promising sources of bioactive natural products.

By providing access to a diverse collection of marine-associated yeasts, the IST-Yeasts CC supports the development of innovative solutions in marine biotechnology and marine drug discovery, including the design of more resilient and high-performance algal cultivation systems through targeted co-cultivation strategies.

This work was developed within the scope of the Pacto da Bioeconomia Azul, funded by Portugal’s Recovery and Resilience Plan (PRR) and the European Union – Next Generation EU

🔗 Read the full article: https://doi.org/10.3390/bioengineering13070807
🔗 Explore the yeast collection: https://blueyeastscc.tecnico.ulisboa.pt.

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Screening of Marine Bacteria for Lipase Activity https://ibb.tecnico.ulisboa.pt/screening-of-marine-bacteria-for-lipase-activity/ Sat, 04 Jul 2026 13:03:14 +0000 https://ibb.tecnico.ulisboa.pt/?p=15161 Multiple approaches are available for the identification of novel microbial lipases. Despite the growing importance of metagenomics in bioprospecting, limitations in recombinant protein expression, in particular for lipases, remain. In a recently published paper, Luís C. de Sousa and Carla C. C. R. de Carvalho  and a former MSc student, Ana J. Caeiro (currently PhD student at UGent), demonstrate that culture-based bioprospecting approaches are still valuable. Six isolates presenting high activity were characterized as whole-cell biocatalysts. Genomic analyses of two Gram-negative lipase-producing isolates revealed the presence of several hypothetical genes encoding for lipolytic enzymes, including outer cell-bound enzymes, predicted through the application of machine-learning tools.

Link to paper: https://doi.org/10.3390/microorganisms14061355

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Halophilic Archaea reveal a hidden talent https://ibb.tecnico.ulisboa.pt/halophilic-archaea-reveal-a-hidden-talent/ Thu, 02 Jul 2026 18:25:20 +0000 https://ibb.tecnico.ulisboa.pt/?p=15158 For decades, extremely halophilic archaea – microorganisms that thrive in salt concentrations far exceeding seawater – have been valued mainly for their extraordinary resilience. A newly published study, co-authored by Carla C. C. R. de Carvalho of iBB’s 2BRG group, suggests these extremophiles have another trick up their sleeve.

The researchers collected brine and sediment samples from hypersaline sites scattered across Eurasia through the salt lakes of Russia’s Kulunda Steppe, the marine salterns of Samouco in Portugal and Trapani in Italy, and the salt production fields of Nha Trang and Cam Ranh in Vietnam.

Using enrichment cultures, they went looking for organisms able to grow on hyaluronic acid as their sole source of carbon and energy: a glycosaminoglycan best known for its structural role in skin, joints and connective tissue, and prized by the cosmetics and biomedical industries.

They found it. The isolates that thrived on hyaluronic acid turned out to belong to new species within the genera Natronoarchaeum and Haloarcula, the first haloarchaea ever shown capable of using this compound as an energy source. It’s a small discovery with a big implication: even within one of biology’s most extensively studied groups of extremophiles, entire metabolic pathways were still waiting to be found, with potential relevance for biotechnological applications such as the biodegradation of hyaluronic-acid-based biopolymers.

The study is published in Frontiers in Microbiology: doi: 10.3389/fmicb.2026.1846936

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Multi-omics characterization of developing forebrain organoids unravels the dynamic molecular events of Rett syndrome pathogenesis https://ibb.tecnico.ulisboa.pt/multi-omics-characterization-of-developing-forebrain-organoids-unravels-the-dynamic-molecular-events-of-rett-syndrome-pathogenesis/ Fri, 12 Jun 2026 16:53:21 +0000 https://ibb.tecnico.ulisboa.pt/?p=15125 A team of researchers from iBB, including Margarida Diogo and Tiago Fernandes, has contributed to advancing our understanding of Rett syndrome (RTT), a rare neurodevelopmental disorder primarily caused by mutations in the MECP2 gene. Although RTT results from alterations in a single gene, the molecular events that drive its development remain poorly understood.

Using patient-derived brain organoids and an integrated multi-omics approach, the researchers mapped how changes in gene and protein expression unfold throughout early brain development. Their work revealed disruptions in key biological processes involved in neuronal development and communication, particularly in GABAergic signalling, while also identifying long non-coding RNAs and imprinted genes as potential contributors to RTT pathology.

By providing a detailed view of the molecular mechanisms underlying Rett syndrome, this study offers new clues into how the disorder develops and highlights promising avenues for future research into targeted therapies that could improve the lives of individuals affected by RTT.

Link to publication: https://link.springer.com/article/10.1186/s11689-026-09699-9 

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Celebrating World Oceans Day with Secondary School Students https://ibb.tecnico.ulisboa.pt/celebrating-world-oceans-day-with-secondary-school-students/ Mon, 08 Jun 2026 19:38:36 +0000 https://ibb.tecnico.ulisboa.pt/?p=15122 To mark World Oceans Day 🌍🌊, Professor and Researcher Tina Keller Costa  from DBE and iBB  visited Escola Básica e Secundária de Gama Barros in Cacém (Sintra, Lisbon District) to speak with 8th and 9th grade students about “Ocean and Health”.

The session explored the link between human and marine ecosystem health, introducing the “One Health” concept and the goals of the UN Ocean Decade. Several challenges were discussed, including harmful algal blooms and marine pathogens such as Vibrio bacteria, which can impact human health and are exacerbated by climate change, affecting water quality and food safety.

Tina also presented examples from IST research on fungal pathogens threatening coral health, highlighting the key role of science, evidence-based solutions, and blue biotechnology in promoting both ocean and human health.  🧫 🧬

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Lipase-assisted removal of spin finishes: What if you could strip the lubricants off synthetic textiles without solvents, and get the same result? https://ibb.tecnico.ulisboa.pt/lipase-assisted-removal-of-spin-finishes-what-if-you-could-strip-the-lubricants-off-synthetic-textiles-without-solvents-and-get-the-same-result/ Mon, 01 Jun 2026 10:00:13 +0000 https://ibb.tecnico.ulisboa.pt/?p=15077 The challenge: The textile industry relies on fatty acid ester lubricants such as spin finishes and sizes to manufacture synthetic fibres. Removing these residues conventionally depends on solvent-based processes, which carry significant environmental and health burdens.

What we did: Researchers Luís C. de Sousa and Carla C. C. R. de Carvalho (2BRG), within the EU-funded FuturEnzyme project, demonstrated a greener alternative. Using lipase enzymes produced by project partners and real polyamide-with-elastane textiles supplied by an industrial partner, the team developed both the biocatalytic hydrolysis step and the accompanying washing process.

The outcome that matters: Enzymatic treatment paired with optimized washing conditions removed spin finishes with performance comparable to existing solvent-based methods, proving that a biological process can match the industry standard while offering a cleaner profile.

Why it’s significant:

  • Environmental impact: Replacing solvents with enzymes points toward lower-toxicity, more sustainable textile processing.
  • Industrial relevance: Validation on commercial materials and conditions, not just lab samples, shortens the path to real-world adoption.
  • Collaborative value: A working pipeline spanning enzyme producers, academic researchers, and industrial partners shows the FuturEnzyme model delivering applied results.

The bigger picture: This work moves enzyme-based textile cleaning from concept to credible competitor, supporting the textile sector’s transition toward more sustainable, bio-based manufacturing.

Link to paper: https://doi.org/10.3390/textiles6020056

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MSCA Postdoctoral Fellowships 2026: hosting opportunities at iBB https://ibb.tecnico.ulisboa.pt/msca-fellowships-2026-hosting-opportunities-at-ibb/ Fri, 22 May 2026 18:17:04 +0000 https://ibb.tecnico.ulisboa.pt/?p=15054 iBB is now accepting Expressions of Interest from fellows under the Marie Skłodowska-Curie Actions (MSCA) Postdoctoral Fellowships 2026 call. Whether you are a prospective fellow looking for a host institution or a researcher exploring funding opportunities, the presentation below provides everything you need to know about applying with iBB as your host research centre.

What’s inside the presentation

  • Overview of the MSCA Postdoctoral Fellowships programme
  • Why choose iBB as your host research centre
  • Available research groups and supervisors
  • Application process
  • How to get in touch with us

💡 How to view: Click the button below to open the presentation in a new tab. Use the arrows to navigate between slides.

Ready to apply?

If you are considering iBB as your host for the MSCA Postdoctoral Fellowships, submit your Expression of Interest to let us know about your research interests and potential supervisors.

📅 Application deadline: 15 June 2026 </]

📧 Contact: pre-award@ist-id.pt

Learn more about MSCA Postdoctoral Fellowships: Official EU page

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iBB Participates in the new INNOVALG Project on Sustainable Microalgae Production https://ibb.tecnico.ulisboa.pt/ibb-participates-in-the-new-innovalg-project-on-sustainable-microalgae-production/ Tue, 12 May 2026 17:36:45 +0000 https://ibb.tecnico.ulisboa.pt/?p=15030
INNOVALG is a collaborative R&D project funded under Portugal 2030 – SIID I&D Empresarial : Operações em Copromoção, bringing together industry and academic partners to advance sustainable microalgae production for the food and nutraceutical sectors.

Through the integration of strain development, regenerative fermentation, and AI-supported monitoring systems, INNOVALG aims to develop more efficient, scalable, and sustainable production processes for high-value microalgae.

By using agro-industrial side streams as alternative nutrient sources, the project contributes to a circular and regenerative bioeconomy, helping reduce waste, production costs, and environmental impact.

The project focuses on delivering innovative, science-based ingredients that support sustainability, food innovation, and human health.

Coordinated by Phycoferm Lda, and developed in collaboration with the University of Porto, Instituto Superior Técnico (iBB), and the University of the Azores, INNOVALG reflects a strong partnership between academia and industry to strengthen biotechnology and sustainable innovation in Portugal.

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iBB Supports Cancer Awareness at “Mexer Contra o Cancro” 2026 https://ibb.tecnico.ulisboa.pt/ibb-supports-cancer-awareness-at-mexer-contra-o-cancro-2026/ Mon, 11 May 2026 11:13:47 +0000 https://ibb.tecnico.ulisboa.pt/?p=15023 iBB was happy to take part in the 2026 edition of “Mexer Contra o Cancro”, an initiative organized by the Liga Portuguesa Contra o Cancro at the Centro Desportivo Nacional do Jamor.

This event brought together science, health, sports, and the community with a shared mission: raising awareness about cancer prevention and supporting oncology research in Portugal.

Throughout the day, participants of all ages joined activities that promoted healthier lifestyles and highlighted the importance of scientific research in improving lives.

As part of this initiative, iBB had the opportunity to engage with the public, share the importance of biomedical research, and reinforce the role of science in addressing major health challenges such as cancer.

Thank you to everyone who contributed to this meaningful initiative and to the Liga Portuguesa Contra o Cancro for organizing an event that combines community, wellbeing, and science for a greater purpose.

A special THANK YOU to the iBB researchers who dedicated part of their Saturday to participate in this initiative and link with the community: Nuno Bernardes, Ana Rita Santos, Diogo Dias, Nuno Graça, Sebastião Pereira!

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iBB at Técnico Open Day 2026 https://ibb.tecnico.ulisboa.pt/ibb-at-tecnico-open-day-2026/ Fri, 01 May 2026 15:25:19 +0000 https://ibb.tecnico.ulisboa.pt/?p=15006 The Instituto de Bioengenharia e Biociências (iBB) participated in Técnico Open Day 2026, an open day hosted at the Instituto Superior Técnico, where research groups presented their work to visitors.

iBB contributed to the science fair and associated activities. The team presented examples of current research and laboratory practices to the public.

The activities included:

  • Demonstrations of how laboratory work may be affected by automation and digital tools
  • An introduction to fungi and their role in biological systems
  • Educational activities for younger visitors showing how light is used to study molecules
  • Examples of how microorganisms are present in everyday environments
  • A demonstration of microbiology methods used in research laboratories

The lab was also opened for visits, where researchers showed basic microbiology techniques and explained their applications.

According to the organizers, the event received more than 4,000 visitors.

More information about the event is available here:
https://tecnico.ulisboa.pt/pt/noticias/campus-e-comunidade/tecnico-recebeu-mais-de-3300-visitantes-na-maior-edicao-de-sempre-do-dia-aberto/

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