Miguel Cacho Teixeira
Associate Professor with Habilitation

Research Activities
• Mechanisms of antifungal drug resistance in Candida glabrata
• Fungal pathogenesis
• Yeast physiology and Molecular Biology
• Genomics, proteomics and transcriptomics
• Systems biology tools for the study of transcriptional regulatory networks
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Selected Publications
Pais, P.*, Vagueiro, S.*, Mil-Homens, D., Pimenta, A.I., Viana, R., Okamoto, M., Chibana, H., Fialho, A.M., Teixeira, M.C., A new regulator in the crossroads of oxidative stress resistance and virulence in Candida glabrata: the transcription factor CgTog1, Virulence, 11(1):1522-1538, 2020.
Viana, R., Dias, O., Lagoa, D., Galocha, M., Rocha, I.**, Teixeira, M.C.**, Genome-scale metabolic model of the human pathogen Candida albicans: a platform for drug target prediction, Journal of Fungi, 6: 171, 2020.

Pais, P., California, R., Galocha, M., Viana, R., Ola, M., Cavalheiro, M., Takahashi-Nakaguchi, A., Chibana, H., Butler, G., Teixeira, M.C., Candida glabrata transcription factor Rpn4 mediates fluconazole resistance through regulation of ergosterol biosynthesis and plasma membrane permeability, Antimicrobial Agents and Chemotherapy, 64: e00554-20, 2020.
Cavalheiro, M., Costa, C., Silva-Dias, A., Miranda, I.M., Wang, C., Pais, P., Pinto, S.N., Mil-Homens, D., Sato-Okamoto, M., Takahashi-Nakaguchi, A., Silva, R.M., Mira, N.P., Fialho, A.M., Chibana, H., Rodrigues, A.G., Butler, G., Teixeira, M.C., Unveiling the mechanisms of in vitro evolution towards fluconazole resistance of a Candida glabrata clinical isolate: a transcriptomics approach, Antimicrobial Agents and Chemotherapy, 63: e00995-18, 2019.
Monteiro, P.T., Pais, P., Costa, C., Manna, S., Sá-Correia, I., Teixeira, M.C., The PathoYeastract database: an information system for the analysis of gene and genomic transcription regulation in pathogenic yeasts, Nucleic Acids Research, 45(D1):D597-D603, 2017.
Santos, R., Costa, C., Mil-Homens, D., Romão, D., de Carvalho, C.C.R., Pais, P., Mira, N.P., Fialho, A.M., Teixeira, M.C., The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogen Candida glabrata", Cellular Microbiology, 19(5): e12686, 2017.

Pais, P., Costa, C., Pires, C., Shimizu, K., Chibana, H., Teixeira, M.C., Membrane proteome-wide response to the antifungal drug clotrimazole in Candida glabrata: role of the transcription factor CgPdr1 and the Drug:H+ Antiporters CgTpo1_1 and CgTpo1_2, Molecular and Cellular Proteomics, 15(1):57-72, 2016.

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