Leonilde de Fátima Morais Moreira
Assistant Professor

Research Activities
- Comparative genomics to understand long-term evolution of Burkholderia multivorans isolates from cystic fibrosis patients
- Mucoid morphotype variation in Burkholderia cepacia complex clinical isolates
- Role of protein tyrosine phosphorylation in bacterial physiology and interaction with host cells

Selected Publications
Silva IN, Pessoa FD, Ramires MJ, Santos MR, Becker JD, Cooper VS, Moreira LM. (2018). The OmpR regulator of Burkholderia multivorans controls mucoid-to-nonmucoid transition and other cell envelope properties associated with persistence in the cystic fibrosis lung. Journal of Bacteriology. 200:e00216-18. doi:10.1128/JB.00216-18.

Silva IN, Ramires MJ, Azevedo LA, Guerreiro AR, Tavares AC, Becker JD, Moreira LM. (2017). Regulator LdhR and D-lactate dehydrogenase LdhA of Burkholderia multivorans play roles in carbon overflow and in planktonic cellular aggregate formation. Applied and Environmental Microbiology 83:e01343-17. doi:10.1128/AEM.01343-17

Silva IN, Santos PM, Santos MR, Zlosnik JEA, Speert DP, Buskirk SW, Bruger EL, Waters CM, Cooper VS, and Moreira LM. (2016). Long-term evolution of Burkholderia multivorans during a chronic cystic fibrosis infection reveals shifting forces of selection. mSystems 1(3):e00029-16. doi:10.1128/mSystems.00029-16.

Ferreira AS, Silva IN, Fernandes F, Pilkington R, Callaghan M, McClean S, Moreira LM. (2015). The tyrosine kinase BceF and the phosphotyrosine phosphatase BceD of Burkholderia contaminans are required for efficient invasion and epithelial disruption of a cystic fibrosis lung epithelial cell line. Infection and Immunity 83:812-821. doi:10.1128/IAI.02713-14.

Medema et al. (2015). Minimum information about a biosynthetic gene cluster. Nature Chemical Biology 11(9):625-631. doi: 10.1038/nchembio.1890.

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