Fábio M. Fernandes
Assistant Professor

Research Activities
My research interests are on the field of Molecular and Cellular Biophysics. I am focused on the development and implementation of state-of-the-art biophysical techniques, namely Förster Resonance energy Transfer (FRET) microscopy and spectroscopy to characterize molecular interactions and biomembrane nanoscale heterogeneities (specifically regarding bioactive lipids), in animal, fungal and bacterial cells. Additionally, I am also interested in the development and characterization of novel biomaterials intended for nanomedicine applications.

Selected Publications
Dao T, Fernandes F, Fauquignon M, Ibarboure E, Prieto M, Le Meins J-F (2018) The combination of block copolymers and phospholipids to form Giant Hybrid Unilamellar Vesicles (GHUVs) does not systematically lead to “intermediate” membrane properties. Soft Matter 14, 6476-6484. doi: 10.1039/C8SM00547H.

Godinho CP, Prata CS, Pinto SN, Cardoso C, Bandarra NM, Fernandes F, Sá-Correia I (2018) Pdr18 is involved in yeast response to acetic acid stress counteracting the decrease of plasma membrane ergosterol content and order, Sci. Rep. 8: 7860, doi:10.1038/s41598-018-26128-7.

Sarmento MJ, Coutinho A, Fedorov A, Prieto M, Fernandes, F (2017) Membrane order is a key regulator of divalent cation-induced clustering of PI(3,5)P2 and PI(4,5)P2. Langmuir 33:12463-12477, doi:10.1021/acs.langmuir.7b00666

Dao TPT, Fernandes F, Ibarboure E, Ferji K, Prieto M, Sandre O, Le Meins J-F (2017) Modulation of phase separation at the micron scale and nanoscale in giant polymer/lipid hybrid unilamellar vesicles (GHUVs), Soft Matter 13: 627-637, doi: 10.1039/C6SM01625A

Sousa T, Castro RE, Pinto SN, Coutinho A, Lucas SD, Moreira R, Rodrigues CMP, Prieto M, Fernandes F (2015) Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties, J. Lipid Res. 56: 2158-2171, doi:10.1194/jlr.M062653

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