Ana M. Melo

Research Activities
My research interests are focused on understanding the aggregation-prone structures and the function/dysfunction of intrinsically disordered amyloidogenic proteins involved in neurodegeneration. Specifically, I use single-molecule techniques (including FCS and single-molecule FRET) to study protein conformations/dynamics, protein-protein interactions, and protein-lipid interactions. My research has been focused on tau (Alzheimer’s disease) and huntingtin (Huntington’s disease) proteins.

Selected Publications
Melo AM, Elbaum-Garfinkle S, Rhoades E (2017) Insights into tau function and dysfunction through single molecule fluorescence, Methods in Cell Biology 141: 27-44, doi: 10.1016/bs.mcb.2017.06.010

Melo AM, Coraor J, Alpha-Cobb G, Elbaum-Garfinkle S, Nath A, Rhoades E (2016) A functional role for intrinsic disorder in the tau-tubulin complex, Proc. Natl. Acad. Sci. U.S.A. 113: 14336-14341. Highlighted on F1000 Prime, doi: 10.1073/pnas.1610137113

Jülich D, Cobb G, Melo AM, McMillen P, Lawton AK, Mochrie SGJ, Rhoades E, Holley SA (2015) Cross-scale Integrin regulation organizes ECM and tissue topology, Dev. Cell 34(1): 33-44, doi: 10.1016/j.devcel.2015.05.005

Melo AM, Fedorov A, Prieto M, Coutinho A (2014) Exploring homo-FRET to quantify the oligomer stoichiometry of membrane-bound proteins involved in a cooperative partition equilibrium, Phys. Chem. Chem. Phys. 16: 18105-18117 (Journal back cover), doi: 10.1039/c4cp00060a

Melo A.M, Loura LMS, Fernandes F, Villalaín J, Prieto M, Coutinho A (2014) Electrostatically driven lipid–lysozyme mixed fibers display a multilamellar structure without amyloid features, Soft Matter, 10: 840-850 (Journal back cover), doi: 10.1039/C3SM52586D

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