Filipa de Canaveira Roque Baker

PhD Student

Research Activities

Study of the mechanisms of resistance and tolerance of yeast to weak acids and ethanol, mainly based on genome-wide approaches, and focused on the eukaryotic model Saccharomyces cerevisiae and on Zygosaccharomyces bailii, considered to be the most problematic food spoilage yeast. Integration of the obtained knowledge, using genomic–scale metabolic models, to guide the design of improved strains and process conditions in the context of the food and bio-ethanol industry.


Selected Publications


Mira, N.P., Münsterkötter, M., Valada, F.D., Santos, J., Palma, M., Roque, F.C., Guerreiro, J.F., Rodrigues, F., Sousa, M.J., Leão, C., Güldener, U. and Sá-Correia, I., The Genome Sequence of the Highly Acetic Acid-Tolerant Zygosaccharomyces bailii-Derived Interspecies Hybrid Strain ISA1307, Isolated From a Sparkling Wine Plant, DNA Research, Volume 21, pages 299–313, 2014.


Lourenço, A.B., Roque, F.C., Teixeira, M.C., Ascenso, J.R., Sá-Correia, I., Quantitative 1H-NMR-Metabolomics Reveals Extensive Metabolic Reprogramming and the Effect of the Aquaglyceroporin FPS1 in Ethanol-Stressed Yeast Cells, PLOS ONE, Volume 8, Issue 2, e55439, 2013.


de Kok, S., Nijkamp, J.F., Oud, B., Roque, F.C., de Ridder, D., Daran, J.M., Pronk, J.T., van Maris, A.J., Laboratory evolution of new lactate transporter genes in a jen1Δ mutant of Saccharomyces cerevisiae and their identification as ADY2 alleles by whole-genome resequencing and transcriptome analysis, FEMS Yeast Research, Volume 12, Issue 3, pages 359–374, 2012.




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