Filipe R. Carvalho

PhD student

Research Activities

The use of miniaturized devices in order to enhance the pace of bioprocess development.


Development and implementation of biocatalytic systems, using free or immobilized biocatalysts.


Comprehensive characterization of immobilized enzymes in silica substrates, namely by: Quartz Crystal Microbalance, X-ray Photoelectron Spectroscopy and Atomic Force Microscopy.


Whole cell biocatalysis in non-conventional media.


Enzyme production by filamentous fungi in submerged and solid state fermentation and subsequent purification.


Favored model systems: Enzymatic modification of carbohydrates. Whole cell modification of sterol/steroid molecules.

Selected Publications


F. Carvalho, P. Paradiso, P. Fernandes, “A microscopic perspective of a microreactor”, Microscopy and Microanalysis, 19, 33-34 (2013)


Pedro Carlos de Barros Fernandes, Filipe Daniel Ramos de Carvalho, Marco Marques, "Miniaturization in Biotechnology: Speeding up the Development of Bioprocesses", Recent Patents on Biotechnology, 5 (3), 160-173 (2011)


Marques, M.P.C., Carvalho, F., de Carvalho, C.C.C.R., Cabral, J.M.S., Fernandes, P., “Steroid bioconversion: Towards green processes”, Food and Bioproducts Processing, 88 (1), 12-20 (2010)


Carvalho, F., Marques, M. P. C., Carvalho C. C. C. R., Cabral, J. M. S., Fernandes, P. “Sitosterol bioconversion with resting cells in liquid polymer based systems”, Bioresource Technol., 100, 4050-4053 (2009)


Marques MPC, Carvalho F, Magalhães S, Cabral JMS, Fernandes P, "Screening for suitable solvents as substrate carriers for the microbial side-chain cleavage of sitosterol using microtitre plates", Process Biochem. 44, 174-180 (2009)

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