Aruna Santhagunam
PhD student
Research
Interests
My research work aims at establishing an efficient and safe non-viral
based
methodology to genetically engineer Synovial Mesenchymal Stromal Cells
(MSCs) to rapidly promote the ex-vivo formation of cartilage for the
treatment of Osteoarthritis (OA) or Rheumatoid arthritis (RA). The work
involves the novel trend in Gene activated matrix (GAM), a
biodegradable scaffold (where the evaluated bioactive compound could be
included) including plasmid DNA previously complexed with cationic
polymers would be developed.
Selected Publications
Santhagunam A, Madeira C, Cabral JM. Genetically engineered stem cell-based strategies for articular cartilage regeneration. Biotechnol Appl Biochem. 59(2):121-31(2012)
Santhagunam A, Dos Santos F, Salgueiro J. B, Madeira C, Cabral JM.Isolation and ex vivo expansion of synovial mesenchymal stromal cells for cartilage repair. Cytotherapy.1-4(2013)
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