Tiago G. Fernandes
Assistant Professor
Research Activities
My work is focused on providing an integrated platform that brings together engineering and biology in order to accelerate progress towards designing the stem cell fate and its microenvironment. The development of artificial cellular niches for studying the mechanisms that affect human stem cell pluripotency is of foremost importance and represents a major goal of my research. The final goal is to generate cells and tissues to advance our understanding of biology and tissue regeneration, which will lead to further development of cell-based therapies.
Selected Publications
Miranda, C.C., Fernandes, T.G., Diogo, M.M., Cabral, J.M.S. (2018) Towards Multi-Organoid Systems for Drug Screening Applications Bioengineering (Basel). 5(3). pii: E49 https://www.ncbi.nlm.nih.gov/pubmed/29933623
Miranda, C.C., Fernandes, T.G., Pinto, S.N., Prieto, M., Diogo, M.M., Cabral, J.M.S. (2018) A scale out approach towards neural induction of human induced pluripotent stem cells for neurodevelopmental toxicity studies Toxicol Lett. 294:51-60 https://www.ncbi.nlm.nih.gov/pubmed/29775723
Dias, T.P., Pinto, S.N., Santos, J.I., Fernandes, T.G., Fernandes, F., Diogo, M.M., Prieto, M., Cabral, J.M.S. (2018) Biophysical study of human induced Pluripotent Stem Cell-Derived cardiomyocyte structural maturation during long-term culture Biochem Biophys Res Commun. 499(3):611-617 https://www.ncbi.nlm.nih.gov/pubmed/29601816
Miranda, C.C., Fernandes, T.G., Diogo, M.M., Cabral, J.M.S. (2016) Scaling up a chemically-defined aggregate-based suspension culture system for neural commitment of human pluripotent stem cells Biotechnol J. 11(12):1628-1638
https://www.ncbi.nlm.nih.gov/pubmed/27754603
Badenes, S.M., Fernandes, T.G., Cordeiro, C.S., Boucher, S., Kuninger, D., Vemuri, M.C., Diogo, M.M., Cabral, J.M.S. (2016) Defined Essential 8™ Medium and Vitronectin Efficiently Support Scalable Xeno-Free Expansion of Human Induced Pluripotent Stem Cells in Stirred Microcarrier Culture Systems PLoS One. 11(3):e0151264
https://www.ncbi.nlm.nih.gov/pubmed/26999816
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Alternative webpages
SCERG
ORCID