Sílvia Andreia Bento da Silva Sousa Barbosa

Researcher with PhD

Research Activities

Microbiology of lung infections in cystic fibrosis patients. In particular, the identification and characterization of virulence factors of bacteria of the Burkholderia cepacia complex (Bcc), with the objective to identify new targets for the development of new antimicrobials. Identification and exploitation of the immunogenic properties of proteins of the Bcc to design new diagnostic and therapeutic strategies to fight the infections caused by these pathogens.

Selected Publications

Sousa, S.A., Feliciano, J.R., Pinheiro, P.F., Leitão, J.H., ”Biochemical and functional studies on the Burkholderia cepacia complex bceN gene, encoding a GDP-D-mannose 4,6-dehydratase”. PLoS ONE, 8, e56902, 2013.

Sousa, S.A., Ramos, C.G., Moreira, L.M., Leitão, J.H., “The hfq gene is required for stress resistance and full virulence of Burkholderia cepacia to the nematode Caenorhabditis elegans”. Microbiology, 156, 896-908, 2010.

Sousa, S.A., Ulrich, M., Bragonzi, A., Burke, M., Worlitzsch, D., Leitão, J.H., Meisner, C., Dinauer, M.C., Fiscarelli, E., Eberl, L., Sá-Correia, I., Döring, G., “Virulence of Burkholderia cepacia complex strains in gp91phox-/- mice”. Cellular Microbiology, 9, 2817-2825, 2007.

Sousa, S.A., Moreira, L.M., Wopperer, J., Eberl, L., Sá-Correia, I., Leitão, J.H., “The Burkholderia cepacia bceA gene encodes a protein with phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activities”. Biochemical and Biophysical Research Communications, 353, 200-206, 2007.

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