Maria Margarida Fonseca Rodrigues Diogo

Assistant Professor


Research Activities

My research interests are focused on the development of scalable platforms for highly controlled expansion and differentiation of human pluripotent stem cells (hPSC), including embryonic (hESC) and induced pluripotent stem cells (hiPSC), and their integration with novel scalable and highly selective stem cell-based purification strategies towards the production of functional and safe hPSC-derivatives for regenerative medicine applications as well as for drug screening and disease modelling.

 

Selected Publications


Diogo, M.M., Lobato da Silva, C., Cabral, J.M.S., “Separation Technologies for Stem Cell Bioprocessing”, Biotech Bioeng, 109(11), 2699-709, (2012).


Fernandes-Platzgummer, A., Diogo, M.M., Batista, R.P., Lobato da Silva, C., Cabral, J.M.S., “Scale-up of mouse embryonic stem cell expansion in stirred bioreactors”, Biotech Prog, 27(5), 1421-32 (2011).

Fernandes, T.G., Diogo, M.M., Fernandes-Platzgummer, A., Lobato da Silva, C., Cabral, J.M.S., “Different stages of pluripotency determine distinct patterns of proliferation, metabolism and lineage commitment of embryonic stem cells under hypoxia”, Stem Cell Res, 5(1), 76-89, (2010).

Rodrigues, C.A.V., Diogo, M.M., Lobato da Silva, C., Cabral, J.M.S., "Hypoxia Enhances Proliferation of Mouse Embryonic Stem Cell-derived Neural Stem Cells", Biotech Bioeng, 106(2), 260-270, (2010).

Fernandes, T.G., Diogo, M.M., Clark, D.S., Dordick, J.S., Cabral, J.M.S., “High-throughput cellular microarray platforms: potential applications in drug discovery, toxicology and stem cell research”, Trends Biotech, 27, 342-349, (2009).


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