Leonilde de Fátima Morais Moreira

Assistant Professor

Research Activities

- Long-term evolution of Burkholderia multivorans isolates from cystic fibrosis patients
- Role of protein tyrosine phosphorylation in bacterial physiology and interaction with host cells
- Mucoid morphotype variation in Burkholderia cepacia complex clinical isolates
- Bacterial determinants of the nitrogen fixation symbiosis between Sinorhizobium meliloti and Medicago plants

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Selected Publications

Silva IN, Santos PM, Santos MR, Zlosnik JEA, Speert DP, Buskirk SW, Bruger EL, Waters CM, Cooper VS, and Moreira LM. (2016). Long-term evolution of Burkholderia multivorans during a chronic cystic fibrosis infection reveals shifting forces of selection. mSystems 1(3):e00029-16. doi:10.1128/mSystems.00029-16.

Ferreira AS, Silva IN, Fernandes F, Pilkington R, Callaghan M, McClean S, Moreira LM. (2015). The tyrosine kinase BceF and the phosphotyrosine phosphatase BceD of Burkholderia contaminans are required for efficient invasion and epithelial disruption of a cystic fibrosis lung epithelial cell line. Infection and Immunity 83:812-821. doi:10.1128/IAI.02713-14.

Medema et al. (2015). Minimum information about a biosynthetic gene cluster. Nature Chemical Biology 11(9):625-631. doi: 10.1038/nchembio.1890.

Santos MR, Tomás AT, Becker JD, and Moreira LM. (2014). Sinorhizobium meliloti EmrR regulator is required for efficient colonization of Medicago sativa root nodules. Molecular Plant-Microbe Interactions 27:388-399. doi: 10.1094/MPMI-09-13-0284-R.

Ferreira AS, Silva IN, Oliveira VH, Becker JD, Givskov M, Ryan RP, Fernandes F, and Moreira LM. (2013). Comparative transcriptomic analysis of the Burkholderia cepacia tyrosine kinase bceF mutant reveals a role in tolerance to stress, biofilm formation and virulence. Applied and Environmental Microbiology. 79:3009-3020. doi: 10.1128/AEM.00222-13.

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