Jorge Humberto Gomes Leitão

Associate Professor


Research Activities

Post-transcription regulation of bacterial gene expression, focusing on the roles played by small non-coding regulatory RNAs (sRNAs) and the RNA chaperones Hfq and Hfq2 on the biology and pathogenesis of Burkholderia cepacia complex bacteria.
Exopolysacharide biosynthesis by Gram-negative bacteria, focusing on the functional analysis of enzymes and proteins involved in biosynthesis and regulation.
Molecular characterization of microbial populations of ecological, industrial or health interest.



Selected Publications

J.R. Feliciano, A.M. Grilo, S.I. Guerreiro, S.A. Sousa, J.H. Leitão. Hfq: a multifaceted RNA chaperone involved in virulence. Future Microbiology (accepted for publication).

 

CG Ramos, AM Grilo, JR Feliciano, PJP da Costa, SA Sousa, JH Leitão. Regulation of Hfq mRNA and protein levels in Escherichia coli and Pseudomonas aeruginosa by the Burkholderia cenocepacia MtvR sRNA. PLoS ONE 9 (6): e98813, 2014


CS Couras, VL Louros, AM Grilo, JH Leitão, MI Capela, LM Arroja, H Nadais. Effects of operational shocks on key microbial populations for biogas production in UASB reactors. Energy 73:866-874, 2014


SA Sousa, JR Feliciano, PF Pinheiro, JH Leitão. Biochemical and functional studies on the Burkholderia cepacia complex bceN gene, encoding a GDP-D-mannose 4,6-dehydratase. PLoS ONE 8: e56902, 2013


CG Ramos, AM Grilo, PJ da Costa, JH Leitão. Experimental identification of small non-coding regulatory RNAs in the opportunistic human pathogen Burkholderia cenocepacia J2315. Genomics 101(2):139-148, 2013



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