Carlos Rodrigues

Post-doctoral fellow

Research Activities

My research at SCBL is focused on the development and operation of bioreactor culture systems for the large-scale expansion and controlled differentiation of neural stem cells (NSC). The successful generation of large numbers of NSC in xeno-free microcarrier-based culture systems and their further differentiation into mature neural phenotypes will facilitate the application of these cells for the treatment of neurodegenerative diseases, neural drug screening and also gene therapy settings.

Selected Publications

Rodrigues, C.A.V., Diogo, M.M., da Silva, C.L., Cabral, J.M.S., “Hypoxia enhances proliferation of mouse embryonic stem cell-derived neural stem cells”, Biotechnology and Bioengineering, 106(2):260-270

Rodrigues, C.A.V., Fernandes, T.G., Diogo, M.M., da Silva, C.L., Cabral, J.M.S., “Stem Cell Cultivation in Bioreactors”, Biotechnology Advances, 29:815–829 (2011)

Rodrigues, C.A.V., Diogo, M.M., da Silva, C.L., Cabral, J.M.S., “Microcarrier Expansion of Mouse Embryonic Stem Cell-Derived Neural Stem Cells in Stirred Bioreactors”, Biotechnology and Applied Biochemistry, 58(4):231-242 (2011)

Madeira, C., Rodrigues, C.A.V., Reis, M.S.C., Ferreira, F.C.G., Correia, R.E.S.M., Diogo MM, Cabral JMS, "Non-viral gene delivery to neural stem cells with minicircles by microporation", Biomacromolecules, 14(5):1379-1387 (2013)

TG Fernandes, CAV Rodrigues, MM Diogo, J Cabral, ” Stem cell bioprocessing for regenerative medicine”, Journal of Chemical Technology and Biotechnology, DOI: 10.1002/jctb.4189 (2013)

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