Cláudia Lobato da Silva

Assistant Professor

Research Activities

I have been focused on the ex-vivo expansion of human stem cells, cellular therapies with human adult and neonatal stem cells, isolation and purification of stem cells, and bioreactors for stem cell culture. In particular, I have been establishing optimal conditions for the maximization of the expansion of umbilical cord blood-derived hematopoietic stem/progenitor cells, as well as developing bioreactor strategies for the clinical-scale production of human mesenchymal stem/stromal cells.

Selected Publications

Andrade, P.Z., dos Santos, F., Cabral, J.M.S., da Silva, C.L., “Stem cell bioengineering strategies to widen the therapeutic applications of haematopoietic stem/progenitor cells from umbilical cord blood”, J. Tissue Eng. Regen. Med. doi: 10.1002/term.1741. (2013)

Andrade, P.Z., de Soure, A.M., dos Santos, F., Paiva, A., Cabral J.M.S., da Silva, C.L., “Ex vivo expansion of cord blood haematopoietic stem/progenitor cells under physiological oxygen tensions: clear-cut effects on cell proliferation, differentiation and metabolism”, J. Tissue Eng. Regen. Med. doi: 10.1002/term.1731. (2013)

Madeira, A., da Silva, C.L., dos Santos, F., Camafeita, E., Cabral, J.M., Sá-Correia, I., “Human Mesenchymal Stem Cell Expression Program upon Extended Ex-vivo Cultivation, as Revealed by 2-DE-Based Quantitative Proteomics”, PLos One 7(8):e43523 (2012)

dos Santos F., Andrade P.Z., Abecasis M.M., Gimble J.M., Chase L.G., Campbell A.M., Boucher S., Vemuri M.C., da Silva C.L., Cabral J.M.S., “Toward a clinical-grade expansion of mesenchymal stem cells from human sources: a microcarrier-based culture system under xeno-free conditions”, Tissue Engineering Part C Methods, 17(12), 1201-10 (2011)

dos Santos, F., Andrade, P.Z., Boura, J.S., Abecasis, M.M.A., da Silva, C.L., Cabral, J.M.S., “Ex Vivo Expansion of Human Mesenchymal Stem Cells: A More Effective Cell Proliferation Kinetics and Metabolism Under Hypoxia”, Journal of Cellular Physiology, 223(1), 27-35 (2010)

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