Carla Patricia da Silva Coutinho

Post-Doctoral research fellow

Research Activities

Molecular and Cellular Microbiology, Functional and Comparative Genomics and Biospectroscopy. Epidemiology and elucidation of adaptive evolution mechanisms adopted by Burkholderia cepacia complex bacteria in respiratory infections of cystic fibrosis patients during long-term lung infection is also an research interest to uncover new persistence and virulence factors and mechanisms that may inspire new therapeutic strategies to treat severe chronic respiratory infections.

Selected Publications

Coutinho, C. P., Sá-Correia, I., and Lopes, J. A. (2009). Use of Fourier transform infrared spectroscopy and chemometrics to discriminate clinical isolates of bacteria of the Burkholderia cepacia complex from different species and ribopatterns. Anal. Bioanal. Chem. 394, 2161–2171.

Coutinho CP, dos Santos SC, Madeira A, Mira NP, Moreira AS, Sá-Correia I. (2011) Long-term colonization of the cystic fibrosis lung by Burkholderia cepacia complex bacteria: epidemiology, clonal variation, and genome-wide expression alterations. Front Cell Inf Microbio 1: 1-11.

Coutinho CP, de Carvalho CC, Madeira A, Pinto-de-Oliveira A, Sá-Correia I. (2011) Burkholderia cenocepacia phenotypic clonal variation during a 3.5-year colonization in the lungs of a cystic fibrosis patient. Infect Immun 79: 2950-2960.

Madeira A, Santos PM, Coutinho CP, Pinto-de-Oliveira A, Sá-Correia I. (2011) Quantitative proteomics (2-D DIGE) reveals molecular strategies employed by Burkholderia cenocepacia to adapt to the airways of cystic fibrosis patients under antimicrobial therapy. Proteomics 11: 1313-1328.

Di Lorenzo F, Silipo A, Lanzetta R, Fazio LL, Paciello I, Coutinho CP, Sá-Correia I, Bernardini M, Molinaro A. (2013) Structural elucidation and biological activity of the lipooligosaccharide of a Burkholderia dolosa isolate from a cystic fibrosis patient. ChemBioChem, 14 (9):1105–1115.

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