Ana Fernandes-Platzgummer

Post-doctoral research fellow

Research Activities

My research addresses the development of efficient, scalable and cost-effective production processes for the large-scale ex-vivo expansion of human adult stem cells (namely hematopoietic and mesenchymal stem cells) in controlled bioreactors.

Selected Publications

Mizukami A, Fernandes-Platzgummer A, Carmelo JG, Swiech K, Covas DT, Cabral JM, da Silva CL. “Stirred tank bioreactor culture combined with serum-/xenogeneic-free culture medium enables an efficient expansion of umbilical cord-derived mesenchymal stem/stromal cells.” Biotechnol J. 2016 May 11. doi: 10.1002/biot.201500532.

Fernandes-Platzgummer A, Diogo MM, da silva CL, Cabral JMS. “Maximizing Mouse Embryonic Stem Cell Production in a Stirred Tank Reactor by Controlling Dissolved Oxygen Concentration and Continuous Perfusion Operation.” Biochem Eng J. 2014, 82, 81-90.

Dos Santos F, Campbell A, Fernandes-Platzgummer A, Andrade PZ, Gimble JM, Wen Y, Boucher S, Vemuri MC, da Silva CL, Cabral JM. “A xenogeneic-free bioreactor system for the clinical-scale expansion of human mesenchymal stem/stromal cells.” Biotechnol Bioeng. 2014 Jun;111(6):1116-27.

Fernandes-Platzgummer A, Diogo MM, Baptista RP, da Silva CL, Cabral JM. “Scale-up of mouse embryonic stem cell expansion in stirred bioreactors.” Biotechnol Prog. 2011 Sep-Oct;27(5):1421-32.

Fernandes AM, Fernandes TG, Diogo MM, da Silva CL, Henrique D, Cabral JM. “Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system.” J Biotechnol. 2007 Oct 31;132(2):227-36.

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